F
Francis J. Huber
Researcher at University of Hamburg
Publications - 6
Citations - 1324
Francis J. Huber is an academic researcher from University of Hamburg. The author has contributed to research in topics: Receptor & Interleukin 10. The author has an hindex of 5, co-authored 5 publications receiving 1132 citations. Previous affiliations of Francis J. Huber include Yale University.
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Journal ArticleDOI
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Samuel Huber,Nicola Gagliani,Lauren A. Zenewicz,Francis J. Huber,Lidia Bosurgi,Bo Hu,Matija Hedl,Wei Zhang,William T. O'Connor,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Carmen J. Booth,Judy H. Cho,Wenjun Ouyang,Clara Abraham,Richard A. Flavell,Richard A. Flavell +17 more
TL;DR: It is described that IL-22BP has a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon in steady-state conditions and the IL- 22–IL-22 BP axis critically regulates intestinal tissue repair and tumorsigenesis in the Colon.
Journal ArticleDOI
Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner
Samuel Huber,Nicola Gagliani,Enric Esplugues,Enric Esplugues,Enric Esplugues,William T. O'Connor,Francis J. Huber,Ashutosh Chaudhry,Masahito Kamanaka,Yasushi Kobayashi,Carmen J. Booth,Alexander Y. Rudensky,Maria Grazia Roncarolo,Manuela Battaglia,Richard A. Flavell,Richard A. Flavell +15 more
TL;DR: It is shown here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor α (IL-10Rα) in vivo, and IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells.
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IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo.
Leonie Brockmann,Nicola Gagliani,Babett Steglich,Anastasios D. Giannou,Jan Kempski,Penelope Pelczar,Maria Geffken,Bechara Mfarrej,Francis J. Huber,Johannes Herkel,Yisong Y. Wan,Enric Esplugues,Manuela Battaglia,Christian Krebs,Richard A. Flavell,Samuel Huber +15 more
TL;DR: TR1 cell regulatory activity is dependent on IL-10 receptor signaling, and data suggest that to optimize TR1 cell–based therapy, IL- 10 receptor expression has to be taken into consideration.
Journal ArticleDOI
A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Dörte Kleinschmidt,Anastasios D. Giannou,Heather M. McGee,Jan Kempski,Babett Steglich,Francis J. Huber,Thomas Ernst,Ahmad Mustafa Shiri,Claudia Wegscheid,Elena Tasika,Peter Hübener,Philipp Huber,Tanja Bedke,Niklas Steffens,Theodora Agalioti,Tobias A. Fuchs,Jill Noll,Hannelore Lotter,Gisa Tiegs,Ansgar W. Lohse,Jonathan H. Axelrod,Eithan Galun,Richard A. Flavell,Nicola Gagliani,Nicola Gagliani,Samuel Huber +25 more
TL;DR: IL-22BP plays a protective role in acute liver damage, via controlling IL-22–induced Cxcl10 expression, and neutralization of CXCL10 reversed the increased disease susceptibility of Il22bp-deficient mice.
Journal ArticleDOI
Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells
Franziska Mathies,Niklas Steffens,Doerte Kleinschmidt,Friederike Stuhlmann,Francis J. Huber,Urmi Roy,Thomas Meyer,M. Luetgehetmann,Mareike von Petersdorff,Oliver Seiz,Johannes Herkel,Christoph Schramm,Richard A. Flavell,Nicola Gagliani,Christian Krebs,Ulf Panzer,Zeinab Abdullah,Till Strowig,Tanja Bedke,Samuel Huber +19 more
TL;DR: Data indicate that colitis can promote a pathological condition of the liver and highlight an important role of Treg in controlling colitis-associated liver inflammation.