N
Nicola Gagliani
Researcher at University of Hamburg
Publications - 118
Citations - 8003
Nicola Gagliani is an academic researcher from University of Hamburg. The author has contributed to research in topics: Immune system & Biology. The author has an hindex of 35, co-authored 91 publications receiving 5974 citations. Previous affiliations of Nicola Gagliani include Vita-Salute San Raffaele University & Karolinska Institutet.
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Journal ArticleDOI
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Nicola Gagliani,Chiara F. Magnani,Samuel Huber,Monica E. Gianolini,Monica E. Gianolini,Mauro Pala,Paula Licona-Limón,Binggege Guo,De'Broski R. Herbert,Alessandro Bulfone,Filippo Trentini,Clelia Di Serio,Rosa Bacchetta,Marco Andreani,Leonie Brockmann,Silvia Gregori,Richard A. Flavell,Maria Grazia Roncarolo +17 more
TL;DR: The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr 1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation.
Journal ArticleDOI
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Nicola Gagliani,Maria Carolina Amezcua Vesely,Andrea Iseppon,Leonie Brockmann,Hao Xu,Noah W. Palm,Marcel R. de Zoete,Paula Licona-Limón,Ricardo Paiva,Travers Ching,Casey T. Weaver,Xiaoyuan Zi,Xinghua Pan,Rong Fan,Lana X. Garmire,Matthew J. Cotton,Yotam Drier,Bradley E. Bernstein,Jens Geginat,Brigitta Stockinger,Enric Esplugues,Samuel Huber,Richard A. Flavell +22 more
TL;DR: Two new fate-mapping mouse models are used to show that CD4+ T cells that formerly expressed IL-17A go on to acquire an anti-inflammatory phenotype and suggest that Th17 cell instability and plasticity is a therapeutic opportunity for inflammatory diseases.
Journal ArticleDOI
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Samuel Huber,Nicola Gagliani,Lauren A. Zenewicz,Francis J. Huber,Lidia Bosurgi,Bo Hu,Matija Hedl,Wei Zhang,William T. O'Connor,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Carmen J. Booth,Judy H. Cho,Wenjun Ouyang,Clara Abraham,Richard A. Flavell,Richard A. Flavell +17 more
TL;DR: It is described that IL-22BP has a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon in steady-state conditions and the IL- 22–IL-22 BP axis critically regulates intestinal tissue repair and tumorsigenesis in the Colon.
Journal ArticleDOI
Control of TH17 cells occurs in the small intestine.
Enric Esplugues,Enric Esplugues,Enric Esplugues,Samuel Huber,Samuel Huber,Nicola Gagliani,Anja E. Hauser,Terrence Town,Terrence Town,Yisong Y. Wan,William T. O'Connor,Anthony Rongvaux,Nico van Rooijen,Ann M. Haberman,Yoichiro Iwakura,Vijay K. Kuchroo,Jay K. Kolls,Jeffrey A. Bluestone,Kevan C. Herold,Richard A. Flavell,Richard A. Flavell +20 more
TL;DR: It is shown that pro-inflammatory TH17 cells can be redirected to and controlled in the small intestine, and mechanisms limiting TH17 cell pathogenicity are identified and implicate the gastrointestinal tract as a site for control of TH 17 cells.
Journal ArticleDOI
Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner
Samuel Huber,Nicola Gagliani,Enric Esplugues,Enric Esplugues,Enric Esplugues,William T. O'Connor,Francis J. Huber,Ashutosh Chaudhry,Masahito Kamanaka,Yasushi Kobayashi,Carmen J. Booth,Alexander Y. Rudensky,Maria Grazia Roncarolo,Manuela Battaglia,Richard A. Flavell,Richard A. Flavell +15 more
TL;DR: It is shown here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor α (IL-10Rα) in vivo, and IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells.