L
Lauren G. Koch
Researcher at University of Toledo
Publications - 247
Citations - 8091
Lauren G. Koch is an academic researcher from University of Toledo. The author has contributed to research in topics: Aerobic exercise & Aerobic capacity. The author has an hindex of 45, co-authored 232 publications receiving 7182 citations. Previous affiliations of Lauren G. Koch include University of Toledo Medical Center & University of Kansas.
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Journal ArticleDOI
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Ulrik Wisløff,Sonia M. Najjar,Øyvind Ellingsen,Per Magnus Haram,Steven J. Swoap,Qusai Y. Al-Share,Mats A. Fernström,Khadijeh Rezaei,Sang Jun Lee,Lauren G. Koch,Steven L. Britton +10 more
TL;DR: After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome and the decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amount of oxidative enzymes in skeletal muscle.
Journal ArticleDOI
Artificial selection for intrinsic aerobic endurance running capacity in rats
Lauren G. Koch,Steven L. Britton +1 more
TL;DR: Artificial selection for intrinsic aerobic endurance running capacity was started using genetically heterogeneous N:NIH stock of rats as a founder population using a velocity-ramped running protocol and produced changes in body weight as a correlated trait.
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Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
James A. Timmons,James A. Timmons,Steen Knudsen,Tuomo Rankinen,Lauren G. Koch,Mark A. Sarzynski,Thomas Jensen,Pernille Keller,Pernille Keller,Camilla Scheele,Camilla Scheele,Niels B. J. Vollaard,Søren Nielsen,Thorbjorn Akerstrom,Ormond A. MacDougald,Eva Jansson,Paul L. Greenhaff,Mark A. Tarnopolsky,Luc J. C. van Loon,Bente Klarlund Pedersen,Carl Johan Sundberg,Claes Wahlestedt,Steven L. Britton,Claude Bouchard +23 more
TL;DR: Combining RNA profiling with single-gene DNA marker association analysis yields a strongly validated molecular predictor with meaningful explanatory power for VO2max responses to endurance training.
Journal ArticleDOI
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
Pernille Keller,Niels B. J. Vollaard,Thomas Gustafsson,Iain J. Gallagher,Carl Johan Sundberg,Tuomo Rankinen,Steven L. Britton,Claude Bouchard,Lauren G. Koch,James A. Timmons,James A. Timmons +10 more
TL;DR: This analysis provides a comprehensive map of the transcriptomic features important for aerobic exercise-induced improvements in maximal oxygen consumption and found that both the TRT and a homologous subset of the human high responder genes were regulated to a greater degree in high respondser rodent skeletal muscle.
Journal ArticleDOI
Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity
Per Magnus Haram,Ole J. Kemi,Ole J. Kemi,Sang Jun Lee,Marianne Ø. Bendheim,Qusay Y. Al-Share,Helge L. Waldum,Lori J. Gilligan,Lauren G. Koch,Steven L. Britton,Sonia M. Najjar,Ulrik Wisløff +11 more
TL;DR: It is demonstrated that exercise training reduces the impact of the metabolic syndrome and that the magnitude of the effect depends on exercise intensity.