Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
James A. Timmons,James A. Timmons,Steen Knudsen,Tuomo Rankinen,Lauren G. Koch,Mark A. Sarzynski,Thomas Jensen,Pernille Keller,Pernille Keller,Camilla Scheele,Camilla Scheele,Niels B. J. Vollaard,Søren Nielsen,Thorbjorn Akerstrom,Ormond A. MacDougald,Eva Jansson,Paul L. Greenhaff,Mark A. Tarnopolsky,Luc J. C. van Loon,Bente Klarlund Pedersen,Carl Johan Sundberg,Claes Wahlestedt,Steven L. Britton,Claude Bouchard +23 more
TLDR
Combining RNA profiling with single-gene DNA marker association analysis yields a strongly validated molecular predictor with meaningful explanatory power for VO2max responses to endurance training.Abstract:
A low maximal oxygen consumption (Vo2max) is a strong risk factor for premature mortality. Supervised endurance exercise training increases Vo2max with a very wide range of effectiveness in human...read more
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Lack of exercise is a major cause of chronic diseases
TL;DR: Physical inactivity is a primary cause of most chronic diseases as discussed by the authors, and the body rapidly maladapts to insufficient physical activity, and if continued, results in substantial decreases in both total and quality years of life.
Journal ArticleDOI
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
TL;DR: The metabolic responses and molecular mechanisms that underpin the adaptatation of skeletal muscle to acute exercise and exercise training are reviewed.
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Exercise is the Real Polypill
TL;DR: In this article, a review summarizes the current body of knowledge on the main biological mediators (ingredients) of the preventive/therapeutic effects of regular exercise, and summarizes their roles.
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Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs
TL;DR: The idea is that blood flow to the contracting muscle links oxygen in the atmosphere with the contracting muscles where it is consumed in order to link oxygen with the muscle, and the vasodilating factors in the muscle are responsible for these very high flows.
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Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling
TL;DR: Accumulating data indicate that exercise with moderate intensity has systemic and complex health-promoting effects, which undoubtedly involve regulation of redox homeostasis and signaling.
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