T
Thomas Gustafsson
Researcher at Karolinska University Hospital
Publications - 164
Citations - 8562
Thomas Gustafsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Skeletal muscle & Vascular endothelial growth factor. The author has an hindex of 44, co-authored 152 publications receiving 7326 citations. Previous affiliations of Thomas Gustafsson include King's College London & Karolinska Institutet.
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Journal ArticleDOI
Limb proportions show developmental plasticity in response to embryo movement.
Andrea S. Pollard,B G Charlton,John R. Hutchinson,Thomas Gustafsson,Imelda M. McGonnell,James A. Timmons,Andrew A. Pitsillides +6 more
TL;DR: It is shown that incubation temperature influences motility and limb bone growth in West African Dwarf crocodiles, producing altered limb proportions which may, influence post-hatching performance and provide new insights into how environmental factors can be integrated to influence cellular activity in growing bones and ultimately gross limb morphology, to generate phenotypic variation during prenatal development.
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Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle
TL;DR: VEGF but not FGF-2 gene expression is upregulated in human skeletal muscle by a single bout of dynamic exercise and there is a graded response in VEGF mRNA expression related to the metabolic stress.
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PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
Jessica Norrbom,Carl Johan Sundberg,Helene Ameln,William E. Kraus,Eva Jansson,Thomas Gustafsson +5 more
TL;DR: A novel finding was that, in human skeletal muscle, PGC-1alpha mRNA increased more after exercise with restricted blood flow than in the nonrestricted condition, which suggests that calcineurin may be activated by exercise in humans and does not exclude that calcinesurin could play a role in P GC-1 transcription activation inhuman skeletal muscle.
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Physiological activation of hypoxia inducible factor-1 in human skeletal muscle
Helene Ameln,Thomas Gustafsson,Carl Johan Sundberg,Kensaku Okamoto,Kensaku Okamoto,Eva Jansson,Lorenz Poellinger,Yuichi Makino,Yuichi Makino +8 more
TL;DR: It is demonstrated that physical activity induces the HIF‐1‐mediated signaling pathway in human skeletal muscle, providing the first evidence that human Hif‐1α can be activated during physiologically relevant conditions.
Journal ArticleDOI
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
Pernille Keller,Niels B. J. Vollaard,Thomas Gustafsson,Iain J. Gallagher,Carl Johan Sundberg,Tuomo Rankinen,Steven L. Britton,Claude Bouchard,Lauren G. Koch,James A. Timmons,James A. Timmons +10 more
TL;DR: This analysis provides a comprehensive map of the transcriptomic features important for aerobic exercise-induced improvements in maximal oxygen consumption and found that both the TRT and a homologous subset of the human high responder genes were regulated to a greater degree in high respondser rodent skeletal muscle.