Steven W. Wingett

TL;DR: In this article, the authors use Capture Hi-C (CHi-C) to examine the long-range interactions of almost 22,000 promoters in 2 human blood cell types and identify over 1.6 million shared and cell type-restricted interactions spanning hundreds of kilobases between promoters and distal loci.

TL;DR: This work uses promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types and shows that promoter interactions are highly cell type specific and enriched for links between active promoters and epigenetically marked enhancers.

TL;DR: FastQ Screen is a tool to validate the origin of DNA samples by quantifying the proportion of reads that map to a panel of reference genomes and is intended to be used routinely as a quality control measure and for analysing samples in which theorigin of the DNA is uncertain or has multiple sources.

TL;DR: It is shown that chromosomal compartments, topological-associated domains (TADs), contact insulation and long-range loops, all defined by bulk Hi-C maps, are governed by distinct cell-cycle dynamics, while loops are generally stable from G1 to S and G2 phase.

TL;DR: The pipeline maps data to a specified reference genome and removes artefacts that would otherwise hinder subsequent analysis and produces an easy-to-interpret yet detailed quality control (QC) report that assists in refining experimental protocols for future studies.