L
Laurent Malivert
Researcher at Necker-Enfants Malades Hospital
Publications - 10
Citations - 1413
Laurent Malivert is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: DNA repair & Non-homologous end joining. The author has an hindex of 10, co-authored 10 publications receiving 1355 citations. Previous affiliations of Laurent Malivert include Paris Descartes University & Paris Diderot University.
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Journal ArticleDOI
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Dietke Buck,Laurent Malivert,Régina de Chasseval,Anne Barraud,Marie-Claude Fondanèche,Ozden Sanal,Alessandro Plebani,Jean-Louis Stephan,Markus Hufnagel,Françoise Le Deist,Alain Fischer,Anne Durandy,Jean-Pierre de Villartay,Patrick Revy +13 more
TL;DR: Five patients with growth retardation, microcephaly, and immunodeficiency characterized by a profound T+B lymphocytopenia are described and Cernunnos/XLF represents a novel DNA repair factor essential for the NHEJ pathway.
Journal ArticleDOI
V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.
Pauline Soulas-Sprauel,Paola Rivera-Munoz,Paola Rivera-Munoz,Laurent Malivert,Laurent Malivert,G Le Guyader,G Le Guyader,Vincent Abramowski,Vincent Abramowski,Patrick Revy,Patrick Revy,J-P de Villartay,J-P de Villartay,J-P de Villartay +13 more
TL;DR: V(D)J recombination and CSR represent an interesting paradigm to study the regulation among the various DNA repair pathways.
Journal ArticleDOI
JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.
Isabelle Plo,Isabelle Plo,Mayuka Nakatake,Mayuka Nakatake,Laurent Malivert,Jean-Pierre de Villartay,Stéphane Giraudier,Stéphane Giraudier,Jean-Luc Villeval,Jean-Luc Villeval,Lisa Wiesmüller,William Vainchenker,William Vainchenker +12 more
TL;DR: In a Ba/F3 cell line expressing the erythropoietin (EPO) receptor, mutant JAK2(V617F) and, to a lesser extent, wild-type (wt) JAK1 induced an increase in HR activity in the presence of EPO without modifying nonhomologous end-joining efficiency, highlighting a new molecular mechanism for HR regulation mediated by J AK2 and more efficiently by JAK 2.
Journal ArticleDOI
Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1 *
Isabelle Callebaut,Laurent Malivert,Alain Fischer,Alain Fischer,Jean-Paul Mornon,Patrick Revy,Patrick Revy,Jean-Pierre de Villartay,Jean-Pierre de Villartay +8 more
TL;DR: It is shown here that Cernunnos physically interacts with the XRCC4·DNA-ligase IV complex and that it corresponds to the genuine homolog of the yeast Nej1 protein, shed new lights on the last step, the DNA religation, of the NHEJ pathway.
Journal ArticleDOI
Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and Humans
Gabriella Vera,Paola Rivera-Munoz,Paola Rivera-Munoz,Vincent Abramowski,Laurent Malivert,Laurent Malivert,Annick Lim,Christine Bole-Feysot,Christelle Martin,Benoit Florkin,Sylvain Latour,Sylvain Latour,Patrick Revy,Patrick Revy,Jean-Pierre de Villartay,Jean-Pierre de Villartay,Jean-Pierre de Villartay +16 more
TL;DR: The viability of thymocytes is reduced in Cernunnos KO mice, and the contraction of discrete T cell populations, such as invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, in both humans and mice.