S
Sylvain Latour
Researcher at French Institute of Health and Medical Research
Publications - 135
Citations - 11304
Sylvain Latour is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 53, co-authored 116 publications receiving 10186 citations. Previous affiliations of Sylvain Latour include Columbia University & International Agency for Research on Cancer.
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Journal ArticleDOI
XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome
Stephanie Rigaud,Marie-Claude Fondanèche,Nathalie Lambert,Nathalie Lambert,Benoit Pasquier,Véronique Mateo,Pauline Soulas,Lionel Galicier,Françoise Le Deist,Françoise Le Deist,Frédéric Rieux-Laucat,Patrick Revy,Alain Fischer,Alain Fischer,Geneviève de Saint Basile,Sylvain Latour +15 more
TL;DR: By identifying an XLP immunodeficiency that is caused by mutations in XIAP, it is shown that XIAP is a potent regulator of lymphocyte homeostasis in vivo.
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Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency
Salima Hacein-Bey-Abina,Julia Hauer,Annick Lim,Capucine Picard,Gary P. Wang,Charles C. Berry,Chantal Martinache,Frédéric Rieux-Laucat,Sylvain Latour,Bernd H. Belohradsky,Lily E. Leiva,Ricardo U. Sorensen,Marianne Debré,Jean-Laurent Casanova,Stéphane Blanche,Anne Durandy,Frederic D. Bushman,Alain Fischer,Marina Cavazzana-Calvo +18 more
TL;DR: After nearly 10 years of follow-up, gene therapy was shown to have corrected the immunodeficiency associated with SCID-X1 and may be an option for patients who do not have an HLA-identical donor for hematopoietic stem-cell transplantation and for whom the risks are deemed acceptable.
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Stepwise development of MAIT cells in mouse and human.
Emmanuel Martin,Emmanuel Treiner,Emmanuel Treiner,Livine Duban,Lucia Guerri,Hélène Laude,Cécile Toly,Virginie Premel,Anne Devys,Ivan C. Moura,Florence Tilloy,Stéphane Cherif,Gabriella Vera,Sylvain Latour,Claire Soudais,Olivier Lantz +15 more
TL;DR: MAIT cells are selected by MR1 in the thymus on a non-B non-T hematopoietic cell, and acquire a memory phenotype and expand in the periphery in a process dependent both upon B cells and the bacterial flora.
Journal ArticleDOI
The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation
Marc Daëron,Sylvain Latour,Odile Malbec,Eric Espinosa,Patrick Pina,Suzanne G.M.A. Pasmans,Wolf H. Fridman +6 more
TL;DR: This work shows that the same tyrosine-based inhibitory motif (ITIM), which is highly conserved in murine and human Fc gamma RIIB and that was previously shown to inhibit BCR-dependent B cell activation, was required to regulate TCR- and FcR-dependent cell activation.
Journal ArticleDOI
The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils
Friedemann Kiefer,John H. Brumell,Nadia Al-Alawi,Sylvain Latour,Alec M. Cheng,André Veillette,Sergio Grinstein,Tony Pawson,Tony Pawson +8 more
TL;DR: Results suggest that Syk has specific physiological roles in signaling from FcγRs in neutrophils and macrophages and raise the possibility that in vivo, Syk is involved in signaling events other than those mediated by immunoreceptors.