L
Laurent Sallé
Researcher at University of Caen Lower Normandy
Publications - 36
Citations - 1161
Laurent Sallé is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Repolarization & Myocyte. The author has an hindex of 17, co-authored 33 publications receiving 1009 citations. Previous affiliations of Laurent Sallé include Centre national de la recherche scientifique.
Papers
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Journal ArticleDOI
Molecular Genetics and Functional Anomalies in a Series of 248 Brugada Cases with 11 Mutations in the TRPM4 Channel
Hui Liu,Stéphanie Chatel,Stéphanie Chatel,Stéphanie Chatel,Christophe Simard,Ninda Syam,Laurent Sallé,Vincent Probst,Julie Morel,Gilles Millat,Michel Lopez,Hugues Abriel,Jean-Jacques Schott,Romain Guinamard,Patrice Bouvagnet +14 more
TL;DR: Functional and biochemical studies of 4 selected mutants revealed that these mutations resulted in either a decreased expression or an increased expression of TRPM4 channel, which may both reduce the availability of sodium channel and thus lead to BrS.
Journal ArticleDOI
Anti-SSA/Ro52 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart block.
Pierre Eftekhari,Laurent Sallé,Frank Lezoualc'h,Jeanne Mialet,Monique Gastineau,Jean-Paul Briand,David A. Isenberg,Gilbert J. Fournié,J Argibay,Rodolphe Fischmeister,Sylviane Muller,Johan Hoebeke +11 more
TL;DR: The affinity‐purified antibodies antagonized the serotonin‐induced L‐type Ca channel activation on human atrial cells, which could explain the electrophysiological abnormalities in neonatal lupus.
Journal ArticleDOI
Differential Modulation of L-type Ca2+ Current by SR Ca2+ Release at the T-Tubules and Surface Membrane of Rat Ventricular Myocytes
TL;DR: Modulation of ICa by Ca2+ at the t-tubules and surface sarcolemma of cardiac ventricular myocytes is characterized using the whole-cell patch clamp technique, suggesting that the t.tubules are a key site for the regulation of transsarcolemmal Ca 2+ flux by Ca1+ release from the SR.
Journal ArticleDOI
Quantification of calcium entry at the T-tubules and surface membrane in rat ventricular myocytes.
TL;DR: This study provides the first evidence that the T-tubules are a key site for the regulation of action potential duration in ventricular cardiac myocytes, consistent with the idea that cardiac excitation-contraction coupling largely occurs at the T -tubule dyadic clefts.
Book ChapterDOI
The Non-selective Monovalent Cationic Channels TRPM4 and TRPM5
TL;DR: The ubiquitously expressed TRPM4 channel has been implicated in insulin secretion, the immune response, constriction of cerebral arteries, the activity of inspiratory neurons and cardiac dysfunction, whereas TRPM5 whose expression is more restricted, has until now been mainly implicated in taste transduction.