L
Laurent Taupenot
Researcher at University of California, San Diego
Publications - 68
Citations - 3930
Laurent Taupenot is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chromogranin A & Secretory protein. The author has an hindex of 33, co-authored 68 publications receiving 3702 citations. Previous affiliations of Laurent Taupenot include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
The Chromogranin–Secretogranin Family
TL;DR: The members of the chromogranin–secretogran in family of peptide hormones, biogenic amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system and a variety of neurons.
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Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
Sushil K. Mahata,Daniel T. O'Connor,Manjula Mahata,Seung Hyun Yoo,Laurent Taupenot,Hongjiang Wu,B. M. Gill,R J Parmer +7 more
TL;DR: This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons.
Journal ArticleDOI
Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity.
Jean-Marc Strub,Pascale Garcia-Sablone,Kjersti Lonning,Laurent Taupenot,Pierre Hubert,Van Dorsselaer A,Dominique Aunis,Marie-Hélène Metz-Boutigue +7 more
TL;DR: The structural features of the proteolytic degradation mechanism of chromogranin B/secretOGranin I have been characterized with regard to the possible function of this protein as a precursor of biologically active peptides, and a peptide secretolytin is proposed to name.
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The Neuroendocrine Peptide Catestatin Is a Cutaneous Antimicrobial and Induced in the Skin after Injury
Katherine A. Radek,Belén López-García,Belén López-García,Melanie Hupe,Melanie Hupe,Ingrid R. Niesman,Peter M. Elias,Peter M. Elias,Laurent Taupenot,Laurent Taupenot,Sushil K. Mahata,Sushil K. Mahata,Daniel T. O'Connor,Daniel T. O'Connor,Richard L. Gallo,Richard L. Gallo +15 more
TL;DR: It is shown that Cst is antimicrobial against relevant skin microbes, including gram-positive and gram-negative bacteria, yeast, and fungi, and is upregulated upon injury, thus demonstrating a direct link between the neuroendocrine and cutaneous immune systems.
Journal ArticleDOI
Processing of Chromogranin B in Bovine Adrenal Medulla
Jean-Marc Strub,Pascale Garcia-Sablone,Kjersti Lonning,Laurent Taupenot,Pierre Hubert,Alain Van Dorsselaer,Dominique Aunis,Marie-Hélène Metz-Boutigue +7 more
TL;DR: The structural features of the proteolytic degradation mechanism of chromogranin B/secretOGranin I have been characterized with regard to the possible function of this protein as a precursor of biologically active peptides, and a peptide secretolytin is proposed to name.