L
Lawrence D. True
Researcher at University of Washington
Publications - 321
Citations - 34128
Lawrence D. True is an academic researcher from University of Washington. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 72, co-authored 289 publications receiving 29134 citations. Previous affiliations of Lawrence D. True include United States Department of Veterans Affairs & Emory University.
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Journal ArticleDOI
Thyroid Transcription Factor-1 Is Expressed in Extrapulmonary Small Cell Carcinomas but Not in Other Extrapulmonary Neuroendocrine Tumors
S. Nicholas Agoff,Laura W. Lamps,Abraham T Philip,Mahul B. Amin,Rodney A. Schmidt,Lawrence D. True,Andrew L. Folpe +6 more
TL;DR: Among well- Differentiated neuroendocrine tumors, TTF-1 expression seems to be present only in carcinoid tumors of the lung and medullary carcinomas of the thyroid and may be of differential diagnostic value when dealing with a metastatic well-differentiated neuro endocrine tumor.
Journal ArticleDOI
Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone ☆
Martine Roudier,Lawrence D. True,Celestia S. Higano,Hubert Vesselle,William J. Ellis,Paul H. Lange,Robert L. Vessella,Robert L. Vessella +7 more
TL;DR: The present study highlights the heterogeneity--histologically and immunophenotypically--of metastatic CaP, and suggests that therapy directed to the phenotype of 1 metastasis may have no effect on other metastases in the same patient because of phenotypic heterogeneity.
Journal ArticleDOI
A causal role for ERG in neoplastic transformation of prostate epithelium
Olga Klezovitch,Michael C. Risk,Ilsa Coleman,Jared M. Lucas,Manda Null,Lawrence D. True,Peter S. Nelson,Valeri Vasioukhin,Valeri Vasioukhin +8 more
TL;DR: It is proposed that up-regulation of ERG in human prostate cancer activates cell invasion programs that subsequently displace basal cells by neoplastic epithelium.
Journal ArticleDOI
A molecular correlate to the Gleason grading system for prostate adenocarcinoma
Lawrence D. True,Ilsa Coleman,Sarah Hawley,Ching Ying Huang,David Gifford,Roger Coleman,Tomasz M. Beer,Edward P. Gelmann,Milton W. Datta,Elahe A. Mostaghel,Beatrice S. Knudsen,Paul H. Lange,Robert L. Vessella,Daniel W. Lin,Leroy Hood,Peter S. Nelson,Peter S. Nelson +16 more
TL;DR: In identifying a profile of 86 genes that distinguish high- from low-grade carcinomas, this work has generated a set of potential targets for modulating the development and progression of the lethal prostate cancer phenotype.
Journal Article
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors.
TL;DR: In the Eker rat, short-term inhibition of mTOR by rapamycin was associated with a significant tumor response, including induction of apoptosis and reduction in cell proliferation, and these changes were not accompanied by significant alteration in cyclin D1 and p27 levels.