L
Lawrence D. True
Researcher at University of Washington
Publications - 321
Citations - 34128
Lawrence D. True is an academic researcher from University of Washington. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 72, co-authored 289 publications receiving 29134 citations. Previous affiliations of Lawrence D. True include United States Department of Veterans Affairs & Emory University.
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Analyzing patterns of staining in immunohistochemical studies: application to a study of prostate cancer recurrence.
TL;DR: Analytical approaches that explicitly consider both the frequency and intensity of tissue staining in immunohistochemical studies are introduced, providing greater insight into differences in staining patterns between groups, but possibly lower statistical power than existing, score-based methods.
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Optimized Prostate Brachytherapy Minimizes the Prognostic Impact of Percent of Biopsy Cores Involved With Adenocarcinoma
Rizwan Nurani,Kent E. Wallner,Kent E. Wallner,Gregory S. Merrick,Jeffrey Virgin,Peter F. Orio,Lawrence D. True +6 more
TL;DR: A total of 50% or greater positive biopsy cores is an independent predictor of poor biochemical failure-free survival in patients treated with brachytherapy in patients with intermediate to high risk adenocarcinoma of the prostate.
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A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer.
Jacob Schwartzman,Solange Mongoue-Tchokote,Angela Gibbs,Lina Gao,Christopher L. Corless,Jennifer Jin,Luai Zarour,Celestia S. Higano,Lawrence D. True,Robert L. Vessella,Beth Wilmot,Daniel Bottomly,Shannon K. McWeeney,G. Steven Bova,Alan W. Partin,Motomi Mori,Joshi J. Alumkal +16 more
TL;DR: It is demonstrated that bead arrays offer a high-throughput method to discover novel genes with promoter DNA methylation such as ERG, whose measurement may improve the ability to more accurately detect prostate cancer.
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WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence.
Biaoyang Lin,Angelita G. Utleg,Karsten Gravdal,James T. White,Ole J. Halvorsen,Wei Lu,Lawrence D. True,Robert L. Vessella,Paul H. Lange,Peter S. Nelson,Leroy Hood,Karl-Henning Kalland,Lars A. Akslen +12 more
TL;DR: It is shown that WDR19 protein is localized to cytoplasmic subcellular granules and is expressed exclusively in prostate epithelia and should be added to the list of prostate cancer tissue markers.
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Diagnosing 12 prostate needle cores within an hour of biopsy via open-top light-sheet microscopy
Weisi Xie,Adam K. Glaser,Funda Vakar-Lopez,Jonathan L. Wright,Nicholas P. Reder,Jonathan T. C. Liu,Lawrence D. True +6 more
TL;DR: The one-hour-to-diagnosis (1Hr2Dx) method has the potential to improve patient care by providing an accurate preliminary diagnosis within an hour of biopsy.