L
Lawrence Rosenberg
Researcher at McGill University
Publications - 120
Citations - 7142
Lawrence Rosenberg is an academic researcher from McGill University. The author has contributed to research in topics: Islet & Pancreas. The author has an hindex of 44, co-authored 120 publications receiving 6816 citations. Previous affiliations of Lawrence Rosenberg include Jewish General Hospital & Montreal General Hospital.
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Journal ArticleDOI
Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
Wissal El-Assaad,Jean Buteau,Marie-Line Peyot,Christopher J. Nolan,Raphaël Roduit,Serge Hardy,Erik Joly,Ghassan Dbaibo,Lawrence Rosenberg,Marc Prentki +9 more
TL;DR: The data indicate that FFAs must be metabolized to long chain fatty acyl-CoA to exert toxicity, the effect of which can be reduced by activating fatty acid oxidation.
Journal ArticleDOI
Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship.
Rennian Wang,Lawrence Rosenberg +1 more
TL;DR: Routine islet isolation disrupts the cell-matrix relationship leading to a variety of structural and functional abnormalities, including apoptotic cell death, which can be diminished by restoration of a culture microenvironment that includes matrix proteins.
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Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
Jean Buteau,Wissal El-Assaad,Christopher J. Rhodes,Lawrence Rosenberg,Erik Joly,Marc Prentki +5 more
TL;DR: A potent protective effect of glucagon-like peptide-1 on beta cell gluco-, lipo- and glucolipotoxicity is demonstrated, mediated via protein kinase B activation and possibly its downstream target nuclear factor-κB.
Journal Article
Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16.
Toru Furukawa,William P. Duguid,Lawrence Rosenberg,Jean Viallet,Jean Viallet,Denise A. Galloway,Ming-Sound Tsao,Ming-Sound Tsao +7 more
TL;DR: A reproducible method is reported for the long-term culture of pancreatic duct epithelial cells derived from normal and benign adult human pancreata by infection with a retrovirus containing the E6 and E7 genes of the human papilloma virus 16.
Journal ArticleDOI
Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters.
Ronit Rafaeloff,G L Pittenger,Scott W. Barlow,X F Qin,B Yan,Lawrence Rosenberg,W P Duguid,Vinik Ai +7 more
TL;DR: The data suggest that the INGAP gene is a novel pancreatic gene expressed during islet neogenesis whose protein product is a constituent of Ilotropin and is capable of initiating duct cell proliferation, a prerequisite for is let neogenesis.