C
Christopher J. Nolan
Researcher at Australian National University
Publications - 100
Citations - 7456
Christopher J. Nolan is an academic researcher from Australian National University. The author has contributed to research in topics: Gestational diabetes & Insulin. The author has an hindex of 35, co-authored 90 publications receiving 6718 citations. Previous affiliations of Christopher J. Nolan include Geelong Hospital & Royal Melbourne Hospital.
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Journal ArticleDOI
Islet β cell failure in type 2 diabetes
TL;DR: The major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D).
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Type 2 diabetes across generations: from pathophysiology to prevention and management
TL;DR: Evidence is emerging that a substantial part of diabetes susceptibility is acquired early in life, probably owing to fetal or neonatal programming via epigenetic phenomena, and maternal and early childhood health might, therefore, be crucial to the development of effective prevention strategies.
Journal ArticleDOI
Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
Wissal El-Assaad,Jean Buteau,Marie-Line Peyot,Christopher J. Nolan,Raphaël Roduit,Serge Hardy,Erik Joly,Ghassan Dbaibo,Lawrence Rosenberg,Marc Prentki +9 more
TL;DR: The data indicate that FFAs must be metabolized to long chain fatty acyl-CoA to exert toxicity, the effect of which can be reduced by activating fatty acid oxidation.
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Gestational diabetes mellitus--management guidelines. The Australasian Diabetes in Pregnancy Society.
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Fatty acid signaling in the beta-cell and insulin secretion.
Christopher J. Nolan,S.R. Murthy Madiraju,Viviane Delghingaro-Augusto,Marie-Line Peyot,Marc Prentki +4 more
TL;DR: It is proposed that FAs do this via three interdependent processes, which are assigned to a “trident model” of β-cell lipid signaling, which will allow a better understanding of the mechanisms ofβ-cell compensation and failure in diabetes.