L
Lawrence S. Melvin
Researcher at Pfizer
Publications - 76
Citations - 6700
Lawrence S. Melvin is an academic researcher from Pfizer. The author has contributed to research in topics: Alkyl & Cannabinoid. The author has an hindex of 22, co-authored 76 publications receiving 6447 citations.
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Journal Article
Determination and characterization of a cannabinoid receptor in rat brain.
TL;DR: The criteria for a high affinity, stereoselective, pharmacologically distinct cannabinoid receptor in brain tissue have been fulfilled.
Journal ArticleDOI
Cannabinoid receptor localization in brain
TL;DR: The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.
Journal Article
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.
David R. Compton,Rice Kc,B. R. De Costa,Raj K. Razdan,Lawrence S. Melvin,M R Johnson,Billy R. Martin +6 more
TL;DR: High correlations were demonstrated between binding affinity and in vivo potency in both the rat drug discrimination model and for psychotomimetic activity in humans, and the structure-activity relationship indicated the importance of side chain structure to high-affinity binding.
Journal ArticleDOI
The cannabinoid receptor: biochemical, anatomical and behavioral characterization
Allyn C. Howlett,Michelle Bidaut-Russell,William A. Devane,Lawrence S. Melvin,M. Ross Johnson,Miles Herkenham +5 more
TL;DR: The actions of the active principle of marihuana, delta 9-tetrahydrocannabinol, are mimicked by synthetic cannabinoid agonists showing high potency and enantio-selectivity in behavioral assays, leading to a better understanding of the effects of cannabinoids in the CNS of humans and experimental animals.
Journal Article
Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.
TL;DR: It is postulated that the receptor that is associated with the regulation of adenylate cyclase in vitro may be the same receptor as that mediating analgesia in vivo, and a conceptualization of the cannabinoid analgetic receptor is presented.