L
Lea Marie Becker
Publications - 6
Citations - 37
Lea Marie Becker is an academic researcher. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 3, co-authored 6 publications receiving 37 citations.
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Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Rhythm Shukla,F. Lavore,Sourav Maity,Maik Derks,Chelsea R Jones,Bram J. A. Vermeulen,Adéla Melcrová,Michael A. Morris,Lea Marie Becker,Xiaoqi Wang,Raj Aditya Kumar,João Medeiros-Silva,Roy A M van Beekveld,Alexandre M. J. J. Bonvin,Joseph H. Lorent,Moreno Lelli,James S. Nowick,Harold D. MacGillavry,Aaron J. Peoples,Amy Spoering,Losee Lucy Ling,Dallas Hughes,Wouter H. Roos,Eefjan Breukink,Kim Lewis,Markus Weingarth +25 more
TL;DR: The mechanism of Teixobactin at the atomic level using a combination of solid-state NMR, microscopy, in vivo assays and molecular dynamics simulations was revealed in this paper .
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NMR-derived secondary structure of the full-length Ox40 mRNA 3′UTR and its multivalent binding to the immunoregulatory RBP Roquin
TL;DR: This study serves as a paradigm for an approach in analysing structured RNA-regulatory hubs and their binding by RBPs by using NMR spectroscopy in a divide-and-conquer strategy and providing contributions of RNA elements to Roquin-binding.
Journal ArticleDOI
Aromatic ring flips in differently packed ubiquitin protein crystals from MAS NMR and MD
Diego F. Gauto,O. O. Lebedenko,Lea Marie Becker,Isabel Ayala,Roman J. Lichtenecker,Nikolai R. Skrynnikov,Paul Schanda +6 more
TL;DR: In this article , the authors apply magic-angle spinning NMR, advanced phenylalanine 1H-13C/2H isotope labeling and MD simulation to a protein in three different crystal packing environments to shed light onto possible impact of packing on ring flips.
Aromatic ring flips in differently packed protein crystals: MAS NMR and MD studies of 3 ubiquitin lattices
Diego F. Gauto,O. O. Lebedenko,Lea Marie Becker,Isabel Ayala,Roman J. Lichtenecker,Rozov Nikolai,Skrynnikov,Paul Schanda +7 more
TL;DR: This paper applied magic-angle spinning NMR, advanced phenylalanine 1 H-13 C/2 H isotope labeling and molecular simulations to a protein in three different crystal packing environments to shed light onto possible impact of packing on ring flips.
Journal ArticleDOI
The Rigid Core and Flexible Surface of Amyloid Fibrils Probed by Magic‐Angle‐Spinning NMR Spectroscopy of Aromatic Residues
Lea Marie Becker,Mélanie Berbon,Alicia Vallet,Axelle Grélard,Estelle Morvan,Benjamin Bardiaux,Roman J. Lichtenecker,Matthias Ernst,Antoine Loquet,Paul Schanda +9 more
TL;DR: Aromatic residues in the core of the amyloid fibrils HELLF and HET-s show no sign of ring flips suggesting a rigid core that does not undergo "breathing motions" as discussed by the authors .