Adéla Melcrová

TL;DR: It is demonstrated that lipid membranes have substantial calcium-binding capacity, with several types of binding sites present, and the binding mode depends on calcium concentration with important implications for calcium buffering, synaptic plasticity, and protein-membrane association.

TL;DR: The transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane, indicating how lateral lipid heterogeneity can regulate various ion-induced processes including adsorbed proteins, nanoparticles, and other molecules onto membranes.

TL;DR: The mechanism of Teixobactin at the atomic level using a combination of solid-state NMR, microscopy, in vivo assays and molecular dynamics simulations was revealed in this paper .

TL;DR: The combination of vibrational spectroscopy with theoretical simulations represents a powerful tool for analysing the saccharide structure and the ROA and Raman data can be used to verify the quality of MD force fields and other parameters of computational modeling.

TL;DR: The changes of the membrane properties induced by calcium and cholesterol were additive and largely independent from each other, and at sufficiently high concentrations of calcium or cholesterol, the steric effects hindered a further alteration of membrane organization, i.e., the compressibility limit of membrane structures was reached.