M
Michaela Müller-McNicoll
Researcher at Goethe University Frankfurt
Publications - 31
Citations - 1561
Michaela Müller-McNicoll is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: RNA-binding protein & RNA. The author has an hindex of 13, co-authored 28 publications receiving 1162 citations. Previous affiliations of Michaela Müller-McNicoll include Max Planck Society.
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Journal ArticleDOI
How cells get the message: dynamic assembly and function of mRNA–protein complexes
TL;DR: This work has highlighted the importance of mRNP packaging, which can sort RNAs on the basis of their length and determine mRNA fate through alternative mR NP assembly, processing and export pathways.
Journal ArticleDOI
The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes
Minna-Liisa Änkö,Michaela Müller-McNicoll,Holger Brandl,Tomaz Curk,Črtomir Gorup,Ian Henry,Jernej Ule,Karla M. Neugebauer +7 more
TL;DR: iCLIP analysis led to the discovery that SRSF3 cross-regulates the expression of other SR protein family members, and unique RNA binding properties underlying diverse cellular regulatory mechanisms, with shared as well as unique coding and non-coding targets.
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SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export.
Michaela Müller-McNicoll,Valentina Botti,António Miguel de Jesus Domingues,Holger Brandl,Oliver D. Schwich,Michaela C. Steiner,Tomaz Curk,Ina Poser,Kathi Zarnack,Karla M. Neugebauer +9 more
TL;DR: SRSF3 and SRSF7 couple alternative splicing and polyadenylation to NXF1-mediated mRNA export, thereby controlling the cytoplasmic abundance of transcripts with alternative 3' ends, and are critically evaluated for their potential to act as NXF 1 adaptors that couple pre-mRNA processing to mRNA export.
Journal ArticleDOI
Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals
Marco Preußner,Gesine Goldammer,Alexander Neumann,Tom Haltenhof,Pia Rautenstrauch,Michaela Müller-McNicoll,Florian Heyd +6 more
TL;DR: It is shown that body temperature cycles drive rhythmic SR protein phosphorylation to control an alternative splicing (AS) program, establishing body temperature-driven AS as a core clock-independent oscillator in mammalian peripheral clocks.
Journal ArticleDOI
Auto-regulatory feedback by RNA-binding proteins.
TL;DR: RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range or generates binary, genetic on/off switches important for e.g. cell fate decisions (by positive feedback) is reviewed.