H
Harold D. MacGillavry
Researcher at Utrecht University
Publications - 48
Citations - 3049
Harold D. MacGillavry is an academic researcher from Utrecht University. The author has contributed to research in topics: Postsynaptic density & Postsynaptic potential. The author has an hindex of 20, co-authored 38 publications receiving 2058 citations. Previous affiliations of Harold D. MacGillavry include Netherlands Institute for Neuroscience & VU University Amsterdam.
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Journal ArticleDOI
A trans-synaptic nanocolumn aligns neurotransmitter release to receptors
Ai-Hui Tang,Haiwen Chen,Tuo P. Li,Sarah R. Metzbower,Harold D. MacGillavry,Thomas A. Blanpied +5 more
TL;DR: It is proposed that the nanoarchitecture of the active zone directs action-potential-evoked vesicle fusion to occur preferentially at sites directly opposing postsynaptic receptor–scaffold ensembles.
Journal ArticleDOI
SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Frank Koopmans,Pim van Nierop,Maria Andres-Alonso,Andrea Byrnes,Tony Cijsouw,Marcelo P. Coba,L. Niels Cornelisse,Ryan J. Farrell,Hana L. Goldschmidt,Daniel P. Howrigan,Natasha K. Hussain,Natasha K. Hussain,Cordelia Imig,Arthur P.H. de Jong,Hwajin Jung,Mahdokht Kohansal-Nodehi,Barbara Kramarz,Noa Lipstein,Ruth C. Lovering,Harold D. MacGillavry,Vittoria Mariano,Vittoria Mariano,Huaiyu Mi,Momchil Ninov,David Osumi-Sutherland,Rainer Pielot,Karl-Heinz Smalla,Haiming Tang,Katherine Tashman,Ruud F. Toonen,Chiara Verpelli,Rita Reig-Viader,Kyoko Watanabe,Jan R.T. van Weering,Tilmann Achsel,Tilmann Achsel,Ghazaleh Ashrafi,Nimra Asi,Tyler C. Brown,Pietro De Camilli,Marc Feuermann,Rebecca E. Foulger,Pascale Gaudet,Anoushka Joglekar,Alexandros K. Kanellopoulos,Alexandros K. Kanellopoulos,Robert C. Malenka,Roger A. Nicoll,Camila Pulido,Jaime de Juan-Sanz,Morgan Sheng,Thomas C. Südhof,Hagen Tilgner,Claudia Bagni,Claudia Bagni,Àlex Bayés,Thomas Biederer,Nils Brose,John Jia En Chua,Daniela C. Dieterich,Eckart D. Gundelfinger,Casper C. Hoogenraad,Richard L. Huganir,Richard L. Huganir,Reinhard Jahn,Pascal S. Kaeser,Eunjoon Kim,Michael R. Kreutz,Peter S. McPherson,Neale Bm,Vincent O'Connor,Danielle Posthuma,Timothy A. Ryan,Carlo Sala,Guoping Feng,Steven E. Hyman,Paul Thomas,August B. Smit,Matthijs Verhage +78 more
TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.
Journal ArticleDOI
Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors
TL;DR: The observed clustered architecture of the PSD controlled the amplitude and variance of simulated postsynaptic currents, suggesting several ways in which PSD interior organization may regulate the strength and plasticity of neurotransmission.
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Microglia innately develop within cerebral organoids.
Paul R. Ormel,Renata Vieira de Sá,Emma J. van Bodegraven,Henk Karst,Oliver Harschnitz,Marjolein A. M. Sneeboer,Lill Eva Johansen,Roland van Dijk,Nicky Scheefhals,Amber Berdenis van Berlekom,Eduardo Ribes Martínez,Sandra Kling,Harold D. MacGillavry,Leonard H. van den Berg,René S. Kahn,Elly M. Hol,Elly M. Hol,Lot de Witte,R. Jeroen Pasterkamp +18 more
TL;DR: It is demonstrated that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human micro glia in a three-dimensional brain environment.
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Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system.
TL;DR: It is shown that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies), which indicates that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosome on local basis.