L
Leen Rymenans
Researcher at Katholieke Universiteit Leuven
Publications - 11
Citations - 1921
Leen Rymenans is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Microbiome & Gut flora. The author has an hindex of 5, co-authored 7 publications receiving 1247 citations. Previous affiliations of Leen Rymenans include Vrije Universiteit Brussel & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Population-level analysis of gut microbiome variation
Gwen Falony,Marie Joossens,Marie Joossens,Sara Vieira-Silva,Jun Wang,Youssef Darzi,Youssef Darzi,Karoline Faust,Karoline Faust,Alexander Kurilshikov,Marc Jan Bonder,Mireia Valles-Colomer,Doris Vandeputte,Doris Vandeputte,Raul Y. Tito,Raul Y. Tito,Samuel Chaffron,Samuel Chaffron,Leen Rymenans,Leen Rymenans,Chloë Verspecht,Lise De Sutter,Lise De Sutter,Gipsi Lima-Mendez,Kevin D'hoe,Kevin D'hoe,Karl Jonckheere,Karl Jonckheere,Daniel Homola,Daniel Homola,Roberto Garcia,Roberto Garcia,Ettje F. Tigchelaar,Linda Eeckhaudt,Linda Eeckhaudt,Jingyuan Fu,Liesbet Henckaerts,Alexandra Zhernakova,Cisca Wijmenga,Jeroen Raes,Jeroen Raes +40 more
TL;DR: Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations, and proposed disease marker genera associated to host covariates were found associated to microbiota compositional variation with a 92% replication rate.
Journal ArticleDOI
Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota.
Raul Y. Tito,Samuel Chaffron,Clara Caenepeel,Gipsi Lima-Mendez,Jun Wang,Sara Vieira-Silva,Gwen Falony,Falk Hildebrand,Youssef Darzi,Leen Rymenans,Chloë Verspecht,Peer Bork,Severine Vermeire,Marie Joossens,Jeroen Raes +14 more
TL;DR: It is shown its prevalence is reduced in patients with active IBD and demonstrated that subtype characterisation is essential for assessing the relationship between Blastocystis, microbiota profile and host health, which have direct clinical applications, especially in donor selection for faecal transplantation.
Journal ArticleDOI
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses
David A. Hughes,Rodrigo Bacigalupe,Jun Wang,Jun Wang,Malte C. Rühlemann,Raul Y. Tito,Gwen Falony,Marie Joossens,Sara Vieira-Silva,Liesbet Henckaerts,Leen Rymenans,Chloë Verspecht,Susan M. Ring,Andre Franke,Kaitlin H Wade,Nicholas J. Timpson,Jeroen Raes +16 more
TL;DR: An association between human host genotype and gut microbiome variation is shown and Mendelian randomization analysis was able to estimate associations between microbial traits and disease (including Bifidobacterium and body composition); however, in the absence of clear microbiome-driven effects, caution is needed in interpretation.
Journal ArticleDOI
Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial.
Hanieh-Sadat Ejtahed,Raul Y. Tito,Seyed Davar Siadat,Shirin Hasani-Ranjbar,Zahra Hoseini-Tavassol,Leen Rymenans,Kristin Verbeke,Ahmadreza Soroush,Jeroen Raes,Bagher Larijani +9 more
TL;DR: Despite the weight reduction after metformin intake, the overall faecal microbiota composition remained largely unchanged in obese women, with exception of changes in specific Proteobacterial groups.
Journal ArticleDOI
Dietary Emulsifiers Alter Composition and Activity of the Human Gut Microbiota in vitro, Irrespective of Chemical or Natural Emulsifier Origin.
Lisa Miclotte,Kim De Paepe,Leen Rymenans,Chris Callewaert,Jeroen Raes,Andreja Rajkovic,John Van Camp,Tom Van de Wiele +7 more
TL;DR: It is concluded that dietary emulsifiers can severely impact the gut microbiota, and this seems to be proportional to their emulsifying strength, rather than emulsifier type or origin.