L
Leena Laitinen
Researcher at University of Helsinki
Publications - 16
Citations - 1707
Leena Laitinen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Mesoporous material & Blowing a raspberry. The author has an hindex of 14, co-authored 16 publications receiving 1623 citations.
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Journal ArticleDOI
Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs.
Jarno Salonen,Leena Laitinen,Ann Marie Kaukonen,Jaani Tuura,Mikko Björkqvist,Teemu Heikkilä,Kalle Vähä-Heikkilä,Jouni Hirvonen,Vesa-Pekka Lehto +8 more
TL;DR: Loading of drugs into TCPSi and TOPSi microparticles showed, that in addition to effects regarding the stability of the particles in the presence of aqueous or organic solvents, surface properties will affect compound affinity towards the particle.
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Mesoporous silica material TUD-1 as a drug delivery system.
Teemu Heikkilä,Jarno Salonen,Jaani Tuura,Mohamed S. Hamdy,Guido Mul,Narendra Kumar,Tapio Salmi,D. Yu. Murzin,Leena Laitinen,Ann Marie Kaukonen,Jouni Hirvonen,Vesa-Pekka Lehto +11 more
TL;DR: TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds, and the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen.
Journal ArticleDOI
Evaluation of Mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 Materials as API Carriers for Oral Drug Delivery
Teemu Heikkilä,Jarno Salonen,Jaani Tuura,Narendra Kumar,Tapio Salmi,D. Yu. Murzin,Mohamed S. Hamdy,Guido Mul,Leena Laitinen,Ann Marie Kaukonen,Jouni Hirvonen,Vesa-Pekka Lehto +11 more
TL;DR: The utilization of mesoporous carriers diminished the pH dependency of ibuprofen dissolution, providing an interesting prospect for the formulation of poorly soluble drug compounds.
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Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects.
Satu Vuorela,Kari Kreander,Maarit Karonen,Riina Nieminen,Mari Hämäläinen,Anna Galkin,Leena Laitinen,Juha-Pekka Salminen,Eeva Moilanen,Kalevi Pihlaja,Heikki Vuorela,Pia Vuorela,Marina Heinonen +12 more
TL;DR: Rapeseed, raspberry, and pine bark are promising bioactive sources of plant phenolics selected from among ca.
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Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles.
Päivi Tammela,Leena Laitinen,Anna Galkin,Tero Wennberg,Robert Heczko,Heikki Vuorela,J. Peter Slotte,Pia Vuorela +7 more
TL;DR: The degree of hydroxylation, molecular configuration, and length of the side chain of flavonoids and alkyl gallates seem to have a highly important impact on their membrane affinity as well as on their permeability characteristics in Caco-2 cells.