Lei Feng

TL;DR: A two-photon excited ratiometric fluorescent probe NCMN has been developed and well-characterized for sensitive and selective detection of CYP1A, which holds great promise for bioimaging of endogenous CYp1A in living cells and for further investigation on CYP 1A associated biological functions in complex biological systems.

TL;DR: BnXPI was successfully used to monitor CYP2J2 activity in real-time for various living systems including cells, tumor tissues, and tumor-bearing animals and displayed the best combination of specificity, sensitivity and applicability for detecting CYP 2J2 in vitro and in vivo.

TL;DR: A two-photon ratiometric fluorescent probe NCEN designed and developed for highly selective and sensitive sensing of human carboxylesterase 2 (hCE2) based on the catalytic properties and substrate preference showed great promise for applications in bioimaging of endogenous h CE2 in living cells and in exploring the biological functions of hCE2 in complex biological systems.

TL;DR: The DDAB probe has been successfully used to detect endogenous CE2 in living cells and in vivo for the first time, and the results demonstrate that such detection is highly reliable.

TL;DR: The potential anti-cancer effects of Andro are demonstrated, indicating that Andro could inhibit COX-2 expression through attenuating p300 HAT activity and suppress angiogenesis via VEGF pathway, and thereby could be developed as an antitumor agent for the treatment of breast cancer.