L
Lei Wang
Researcher at Nankai University
Publications - 330
Citations - 14184
Lei Wang is an academic researcher from Nankai University. The author has contributed to research in topics: Escherichia coli & Gene cluster. The author has an hindex of 61, co-authored 294 publications receiving 12616 citations. Previous affiliations of Lei Wang include Tianjin Economic-Technological Development Area & Anhui University of Chinese Medicine.
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Journal ArticleDOI
Structural, serological, and genetic characterization of the O-antigen of Providencia alcalifaciens O40
Olga G. Ovchinnikova,Olga G. Ovchinnikova,Bin Liu,Dan Guo,Nina A. Kocharova,Magdalena Bialczak-Kokot,Alexander S. Shashkov,Lu Feng,Antoni Rozalski,Lei Wang,Yuriy A. Knirel +10 more
TL;DR: The O40-antigen was found to be structurally and serologically related to the O-antigens of P. alcalifaciens O5 and Providencia stuartii O18 and is a part of the capsule-related form of the lipopolysaccharide called K(LPS).
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Identification of the two glycosyltransferase genes responsible for the difference between Escherichia coli O107 and O117 O-antigens.
Quan Wang,Quan Wang,Andrei V. Perepelov,Liuqing Wen,Liuqing Wen,Alexander S. Shashkov,Xiaoting Wang,Xi Guo,Yuriy A. Knirel,Lei Wang +9 more
TL;DR: To identify the gene responsible for the transfer of different sugars, wclY mutants of E. coli O107 and O117 were constructed, and each mutant was complemented with the wClY genes cloned from both O107 or O117, and Structural analysis of the O-antigens of the four recombinant strains identified wcly as a Glc-transferase in O117 and a GlCNAc- transferase inO107.
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Characterization of the CDP-2-Glycerol Biosynthetic Pathway in Streptococcus pneumoniae
Quan Wang,Yanli Xu,Yanli Xu,Andrei V. Perepelov,Wei Xiong,Dongmei Wei,Dongmei Wei,Alexander S. Shashkov,Yuriy A. Knirel,Lu Feng,Lu Feng,Lei Wang +11 more
TL;DR: This is the first time that the biosynthetic pathway of CDP-2-glycerol has been identified biochemically; this pathway provides a method to enzymatically synthesize this compound.
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Structures of the O-polysaccharides of Salmonella enterica O59 and Escherichia coli O15
Andrei V. Perepelov,Bin Liu,Sof'ya N. Senchenkova,Alexander S. Shashkov,Dan Guo,Lu Feng,Yuriy A. Knirel,Lei Wang +7 more
TL;DR: The O-polysaccharide of Salmonella enterica O59 was studied using sugar analysis and 2D (1)H and (13)C NMR spectroscopy, and the following structure of the tetrasaccharide repeating unit was established.
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Loss of the lac Operon Contributes to Salmonella Invasion of Epithelial Cells Through Derepression of Flagellar Synthesis
TL;DR: It is shown that the Lac+ strain is attenuated in vivo and the attenuation of virulence is caused by its defect in epithelial cell invasion, and it is demonstrated that the lac operon decreases Salmonella invasion of epithelial cells through repression of flagellar biosynthesis.