L
Lei Zheng
Researcher at Johns Hopkins University School of Medicine
Publications - 7
Citations - 703
Lei Zheng is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Histone & Transcription (biology). The author has an hindex of 5, co-authored 5 publications receiving 667 citations. Previous affiliations of Lei Zheng include Rockefeller University.
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S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.
TL;DR: These studies link the H2B transcriptional machinery to cell cycle regulators, and possibly to cellular metabolic state (redox status), and set the stage for studies of the underlying mechanisms and the basis for coordinated histone gene expression and coupling to DNA replication.
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Histone 2B (H2B) Expression Is Confined to a Proper NAD+/NADH Redox Status
TL;DR: The studies suggest that the cellular redox status (metabolic states) can directly feedback to gene switching in higher eukaryotes as is commonly observed in prokaryotes.
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Logic of a mammalian metabolic cycle: an oscillated NAD+/NADH redox signaling regulates coordinated histone expression and S-phase progression.
TL;DR: It is proposed that the S- phase NAD+/NADH redox status constitutes a redox signaling, which along with the cyclin E/cdk2 signaling regulates histone expression and S-phase progression.
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Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes.
TL;DR: The concept of one-protein-multiple-function, i.e. moonlighting proteins, is an ever-expanding paradigm as discussed by the authors, and it has been shown that an array of metabolic enzymes can enter the nuclei to carry out moonlighting transcription functions; this phenomenon is conserved from Drosophila to humans.
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Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription *
Li Ling Zheng,Fei Ya Wang,Xiao Xia Cong,Yue Shen,Xi Sheng Rao,Dao Sheng Huang,Wei Fan,Peng Yi,Xin Bao Wang,Lei Zheng,Yi Ting Zhou,Yan Luo +11 more
TL;DR: A novel role of Cpn10 in the spatial regulation of NPAT signaling is revealed and a previously unappreciated link between the heat shock protein and histone transcription regulation is disclosed.