S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.
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TLDR
These studies link the H2B transcriptional machinery to cell cycle regulators, and possibly to cellular metabolic state (redox status), and set the stage for studies of the underlying mechanisms and the basis for coordinated histone gene expression and coupling to DNA replication.About:
This article is published in Cell.The article was published on 2003-07-25 and is currently open access. It has received 544 citations till now. The article focuses on the topics: Histone H2B & Coactivator.read more
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk,Matthew G. Vander Heiden,Marian H. Harris,Arvind Ramanathan,Robert E. Gerszten,Robert E. Gerszten,Ru Wei,Mark D. Fleming,Stuart L. Schreiber,Stuart L. Schreiber,Lewis C. Cantley,Lewis C. Cantley +11 more
TL;DR: It is demonstrated that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo.
Journal ArticleDOI
Activation and signaling of the p38 MAP kinase pathway
Tyler Zarubin,Jiahuai Han +1 more
TL;DR: The role of p38 as a signal transduction mediator is focused on and the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types is examined.
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Glycolysis inhibition for anticancer treatment
TL;DR: The increased dependence of cancer cells on glycolytic pathway for ATP generation provides a biochemical basis for the design of therapeutic strategies to preferentially kill cancer cells by pharmacological inhibition of Glycolysis.
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S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Makoto R. Hara,Nishant Agrawal,Sangwon F. Kim,Matthew B. Cascio,Masahiro Fujimuro,Yuji Ozeki,Masaaki Takahashi,Jaime H. Cheah,Stephanie Tankou,Lynda D. Hester,Christopher D. Ferris,S. Diane Hayward,Solomon H. Snyder,Akira Sawa +13 more
TL;DR: A signalling pathway in which nitric oxide generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to Siah1 (an E3 ubiquitin ligase), nuclear translocation and apoptosis, which is prevented by NO deletion is reported.
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Multifaceted roles of glycolytic enzymes
Jung Whan Kim,Chi V. Dang +1 more
TL;DR: The existence of multifaceted roles of glycolytic proteins suggests that links between metabolic sensors and transcription are established directly through enzymes that participate in metabolism.
References
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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
TL;DR: 21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics.
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
TL;DR: The analysis of two SIR2 mutations supports the idea that this deacetylase activity accounts for silencing, recombination suppression and extension of life span in vivo, and provides a molecular framework of NAD-dependent histone de acetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes.
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Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.
TL;DR: It is shown that recruitment of the p160 class of coactivators is sufficient for gene activation and for the growth stimulatory actions of estrogen in breast cancer supporting a model in which ER cofactors play unique roles in estrogen signaling.
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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.
TL;DR: The reduced forms of the redox cofactors, NAD(H) and NADP(H), strongly enhance DNA binding of the Clock:BMal1 and NPAS2:BMAL1 heterodimers, whereas the oxidized forms inhibit, raising the possibility that food, neuronal activity, or both may entrain the circadian clock by direct modulation of cellular redox state.
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Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis
Juan Méndez,Bruce Stillman +1 more
TL;DR: Using centrifugal elutriation of several human cell lines, it is demonstrated that whereas human Orc2 and hMcm proteins are present throughout the cell cycle, hCdc6p levels vary, being very low in early G1 and accumulating until cells enter mitosis, indicating that the mitotic kinase activity inhibits prereplication complex formation in human cells.