Lene Uhrbom

TL;DR: The results show that an autocrine mechanism of transformation may be an initial or early event in neuro-oncogenesis, and the present model provides an ideal system for studies of genetic mechanisms involved in the development of brain tumors.

TL;DR: It is shown here that Ink4a-Arf deficiency allows for GBM formation from astrocytes and that it enhances tumor incidence in neural progenitor cells, and this data strongly supports the view that one role of loss of Ink4o-ARF in gliomagenesis could be to sensitize astroCytes to transformation through dedifferentiation in response to the appropriate oncogenic stimuli.

TL;DR: This work developed a library of annotated and validated cell lines derived from surgical samples of GBM patients, maintained under conditions to preserve GSC characteristics, and demonstrates that the HGCC lines are tumorigenic, harbor genomic lesions characteristic of GBMs, and represent all four transcriptional subtypes.

TL;DR: It is shown that the cell of origin for glioma may be a committed glial progenitor cell, and platelet-derived growth factor B transfer to OPCs could induce gliomas with an incidence of 33%.

TL;DR: In this article, the authors established libraries of glioma-initiating cell (GIC) clones from patient samples and found extensive molecular and phenotypic variability among clones, including a range of responses to radiation and drugs.