M
Magnus Sundström
Researcher at Uppsala University
Publications - 35
Citations - 1464
Magnus Sundström is an academic researcher from Uppsala University. The author has contributed to research in topics: Colorectal cancer & KRAS. The author has an hindex of 19, co-authored 35 publications receiving 1181 citations. Previous affiliations of Magnus Sundström include Science for Life Laboratory & Uppsala University Hospital.
Papers
More filters
Journal ArticleDOI
Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
Anna Segerman,Anna Segerman,Mia Niklasson,Caroline Haglund,Tobias Bergström,Malin Jarvius,Yuan Xie,Ann Westermark,Demet Sönmez,Annika Hermansson,Marianne Kastemar,Zeinab Naimaie-Ali,Frida Nyberg,Malin Berglund,Magnus Sundström,Göran Hesselager,Lene Uhrbom,Mats Gustafsson,Rolf Larsson,Mårten Fryknäs,Bo Segerman,Bo Segerman,Bengt Westermark +22 more
TL;DR: In this article, the authors established libraries of glioma-initiating cell (GIC) clones from patient samples and found extensive molecular and phenotypic variability among clones, including a range of responses to radiation and drugs.
Journal ArticleDOI
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.
Linnea La Fleur,Elin Falk-Sörqvist,Patrik Smeds,Anders Berglund,Magnus Sundström,Johanna Sofia Margareta Mattsson,Eva Brandén,Hirsh Koyi,Johan Isaksson,Hans Brunnström,Mats Nilsson,Patrick Micke,Lotte Moens,Johan Botling +13 more
TL;DR: Mutational patterns and linked clinical parameters in a population-based NSCLC cohort were described and concurrent mutations in TP53 and STK11 were shown to confer poor survival in the KRAS-positive adenocarcinoma subgroup.
Journal ArticleDOI
Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene
Magnus Sundström,Harissios Vliagoftis,Peter Karlberg,Joseph H. Butterfield,Kenneth Nilsson,Dean D. Metcalfe,Gunnar Nilsson +6 more
TL;DR: Two sublines of HMC‐1 are described with different phenotypes and designated by the locations of specific mutations in the c‐kit proto‐oncogene, providing both information on the biological consequences of mutations in Kit and recognition of the availability of what in reality are two distinct cultured human mast cell lines.
Journal ArticleDOI
Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity.
Markus Rasmussen,Magnus Sundström,Hanna Göransson Kultima,Johan Botling,Patrick Micke,Helgi Birgisson,Bengt Glimelius,Bengt Glimelius,Anders Isaksson +8 more
TL;DR: Analysis of cancer samples indicates that TAPS is well suited to investigate samples with aneuploidy and tumor heterogeneity, which is commonly found in many types of solid tumors.
Journal ArticleDOI
Impact of Thawing on RNA Integrity and Gene Expression Analysis in Fresh Frozen Tissue
Johan Botling,Karolina Edlund,Ulrika Segersten,Simin Tahmasebpoor,Mats Engström,Magnus Sundström,Per-Uno Malmström,Patrick Micke +7 more
TL;DR: It is concluded that degradation of RNA in frozen tissue occurs first after several minutes of thawing, and already minimal decrease in RNA quality may result in significant changes in gene expression patterns in clinical tissue samples.