L
Leo E. Otterbein
Researcher at Beth Israel Deaconess Medical Center
Publications - 228
Citations - 24913
Leo E. Otterbein is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 79, co-authored 221 publications receiving 22713 citations. Previous affiliations of Leo E. Otterbein include Veterans Health Administration & Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
Danger signals from mitochondrial DAMPS in trauma and post-injury sepsis
Carl J. Hauser,Leo E. Otterbein +1 more
TL;DR: Mitochondria are evolutionarily derived from bacteria, and thus they sit at the crossroads between sterile and infective danger signal pathways, and the release of MT from injured cells results in a wide variety of inflammatory events.
Journal ArticleDOI
The Evolution of Carbon Monoxide Into Medicine
TL;DR: As CO moves ahead in the clinic, there is sound preclinical evidence that, at a low concentration, CO has benefits in numerous and diverse diseases in rodents, large animals, and humans.
Journal ArticleDOI
Cross-Regulation of Carbon Monoxide and the Adenosine A2a Receptor in Macrophages
Arvand Haschemi,Oswald Wagner,Rodrig Marculescu,Barbara Wegiel,Simon C. Robson,Nicola Gagliani,David Gallo,Jiang-Fan Chen,Fritz H. Bach,Leo E. Otterbein +9 more
TL;DR: Data suggest the existence of a positive feedback loop among adenosine, HO-1, CO, and the A2aR in the chronological resolution of the inflammatory response.
Patent
Carbon monoxide as a biomarker and therapeutic agent
TL;DR: In this paper, the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult respiratory distress syndrome, sepsis, cystic fibrosis, pneumonia, interstitial lung diseases, idiopathic pulmonary diseases, other lung diseases including lung, larynx and throat cancer, arthritis, wound healing, Parkinson's disease, peripheral vascular disease and pulmonary vascular throm
Journal ArticleDOI
Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule.
Beek Yoke Chin,Leo E. Otterbein +1 more
TL;DR: Reports that have propelled and challenged the paradoxical use of CO, once viewed as a toxic molecule, now as a host defense molecule agent against microbes are reviewed.