L
Leo E. Otterbein
Researcher at Beth Israel Deaconess Medical Center
Publications - 228
Citations - 24913
Leo E. Otterbein is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 79, co-authored 221 publications receiving 22713 citations. Previous affiliations of Leo E. Otterbein include Veterans Health Administration & Johns Hopkins University School of Medicine.
Papers
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Ott, M. C. et al. Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion. FASEB J. 19, 106-108
Jeffrey R. Scott,Leo E. Otterbein,Richard F. Potter,Aurelia Bihari,Amit Badhwar,Michael Ott,Daryl K. Gray,Kenneth A. Harris +7 more
Journal ArticleDOI
Circulating Factors in Trauma Plasma Activate Specific Human Immune Cell Subsets.
Laura A Cahill,Fei Guo,Jennifer P Nguyen,Fan Zhang,Anupamaa J Seshadri,Joshua Keegan,Carl J. Hauser,Leo E. Otterbein,Simon C. Robson,Shahzad Shaefi,Michael B. Yaffe,James A. Lederer +11 more
TL;DR: It is demonstrated that the normal PBMC response to trauma plasma involves marked changes in specific subsets of NK and CD8+ T cell populations, which have important implications for the field of acute traumatic injuries.
Journal ArticleDOI
Clinical Implications of Hyperoxia.
TL;DR: There are emerging clinical data within a variety of arenas that suggest this assumption that excess oxygen is relatively harmless may not be true, and there is renewed interest in potential detrimental consequences of hyperoxia, not only with regard to lung injury but to all organ dysfunction.
Journal ArticleDOI
Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. Vol. 279 (2004) 44327–44334
Ruiping Song,Zhihong Zhou,Peter K. Kim,Richard A. Shapiro,Fang Liu,Christiane Ferran,Augustine M.K. Choi,Leo E. Otterbein +7 more
TL;DR: Fas/CD95-induced cell death in Jurkat cells is augmented by exposure to CO and that this occurs in part via inhibition in the activation of ERK MAPK, which begins to elucidate specific differences with regard to the effects of CO and cell death pathways and provide important and valuable insight into potential mechanisms of action.
Patent
Carbon monoxide releasing molecules and uses thereof
Walter Anton Blättler,Carlos C. Romão,Sandra S. Rodrigues,Lukas Adrian Kromer,Leo E. Otterbein,David Gallo +5 more
TL;DR: In this paper, novel carbon-monoxide releasing molecules (CO-RMs) of the Formula (I): and esters, amides, salts, solvates and hydrates thereof; wherein R 1 and R 2 are as described herein.