L
Leo E. Otterbein
Researcher at Beth Israel Deaconess Medical Center
Publications - 228
Citations - 24913
Leo E. Otterbein is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 79, co-authored 221 publications receiving 22713 citations. Previous affiliations of Leo E. Otterbein include Veterans Health Administration & Johns Hopkins University School of Medicine.
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Journal Article
Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation
Brian S. Zuckerbraun,Carol A. McCloskey,David A. Gallo,Fang Liu,Emeka Ifedigbo,Leo E. Otterbein,Timothy R. Billiar +6 more
TL;DR: Testing the hypothesis that CO protects against hemorrhagic shock- and resuscitation-induced systemic inflammation and end-organ damage demonstrates that delivery of a low concentration of inhaledCO protects against the development of end- organ injury, and paradoxically abrogates hemorrhage-induced hepatic cellular hypoxia.
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Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts
Atsunori Nakao,Kei Kimizuka,Donna B. Stolz,Joao Seda Neto,Takashi Kaizu,Augustine M.K. Choi,Takashi Uchiyama,Brian S. Zuckerbraun,Anthony J. Bauer,Michael A. Nalesnik,Leo E. Otterbein,David A. Geller,Noriko Murase +12 more
TL;DR: Results indicate a significant role for CO in protecting the intestine from cold I/R injury associating with small intestinal transplantation and beneficial effects of CO were associated with improved graft blood flow without inhibiting endogenous HO-1 activity.
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Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs
Silvia Mazzola,Monica Forni,Mariangela Albertini,Maria Laura Bacci,Augusta Zannoni,Fabio Gentilini,Marialuisa Lavitrano,Fritz H. Bach,Leo E. Otterbein,M.G. Clement +9 more
TL;DR: administering CO in a clinically relevant, well‐characterized model of LPS‐induced acute lung injury in pigs significantly ameliorated several of the acute pathological changes induced by endotoxic shock and blunted the deterioration of kidney and liver function.
Journal ArticleDOI
Carbon monoxide protects against the development of experimental necrotizing enterocolitis
Brian S. Zuckerbraun,Leo E. Otterbein,Patricia Boyle,Patricia Boyle,Ronald Jaffe,Jeffrey S. Upperman,Ruben Zamora,Henri R. Ford,Henri R. Ford +8 more
TL;DR: It is found that 1 h of daily low-dose inhaled CO protected against the development of intestinal inflammation in a model of experimental NEC and may prove to be a useful clinical adjunct in the treatment of NEC.
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Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway.
Leo E. Otterbein,Beek Yoke Chin,Sherrie L. Otterbein,Valerie C. Lowe,Henry E. Fessler,Augustine M.K. Choi +5 more
TL;DR: It is concluded that Hb pretreatment reduces the inflammatory and physiological consequences of LPS and that the Hb-induced protection against LPS is dependent on HO-1 and not ferritin induction.