L
Leo E. Otterbein
Researcher at Beth Israel Deaconess Medical Center
Publications - 228
Citations - 24913
Leo E. Otterbein is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 79, co-authored 221 publications receiving 22713 citations. Previous affiliations of Leo E. Otterbein include Veterans Health Administration & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Cystatin C Is Downregulated in Prostate Cancer and Modulates Invasion of Prostate Cancer Cells via MAPK/Erk and Androgen Receptor Pathways
Barbara Wegiel,Thomas Jiborn,Magnus Abrahamson,Leszek Helczynski,Leo E. Otterbein,Jenny L. Persson,Anders Bjartell +6 more
TL;DR: A novel role is uncovered for cystatin C and its associated cellular pathways in prostate cancer invasion and metastasis as well as the association with matrix metalloproteinases 2 and androgen receptor (AR) in a tissue microarray comparing benign and malignant specimens.
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Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells.
Barbara Wegiel,Andreas Hedblom,Mailin Li,D. Gallo,Eva Csizmadia,Clair Harris,Zsuzsanna Németh,B S Zuckerbraun,Miguel P. Soares,Jenny L. Persson,Leo E. Otterbein +10 more
TL;DR: It is concluded that HO-1 and CO in part are critical for myeloid cell differentiation and may prove to be a novel therapeutic agent to improve functional recovery of bone marrow cells in patients undergoing irradiation, chemotherapy and/or bone marrow transplantation.
Journal ArticleDOI
Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion.
Michael Ott,Jeffrey R. Scott,Aurelia Bihari,Amit Badhwar,Leo E. Otterbein,Daryl K. Gray,Kenneth A. Harris,Richard F. Potter +7 more
TL;DR: It is suggested that HO‐derived hepatic protection is mediated by CO, and inhalation of low concentrations of CO may represent a novel therapeutic approach to prevent remote organ injury during systemic inflammatory response syndrome, or SIRS.
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Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation.
Nicola Sandler,Nicola Sandler,Elzbieta Kaczmarek,Kiyoshi Itagaki,Yi Zheng,Leo E. Otterbein,Kamal R. Khabbaz,David Ruchien Liu,Venkatachalam Senthilnathan,Russell L. Gruen,Carl J. Hauser +10 more
TL;DR: Mitochondrial DNA is released by CPB surgery and is associated with POAF, and may be involved in the pathogenesis of SIRS and related postoperative inflammatory events like POAF and infections.
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Bilirubin suppresses Th17 immunity in colitis by upregulating CD39
Maria Serena Longhi,Marta Vuerich,Alireza Kalbasi,Jessica E. Kenison,Ada Yeste,Eva Csizmadia,Byron P. Vaughn,Linda Feldbrügge,Shuji Mitsuhashi,Barbara Wegiel,Leo E. Otterbein,Alan C. Moss,Francisco J. Quintana,Simon C. Robson +13 more
TL;DR: It is noted that UCB modulates T helper type 17 (Th17) immune responses, in a manner dependent upon heightened expression of CD39 ectonucleotidase, which might provide therapeutic options to address development of Th17 dysfunction in IBD.