L
Leo E. Otterbein
Researcher at Beth Israel Deaconess Medical Center
Publications - 228
Citations - 24913
Leo E. Otterbein is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 79, co-authored 221 publications receiving 22713 citations. Previous affiliations of Leo E. Otterbein include Veterans Health Administration & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Inhaled carbon monoxide inhibits intimal hyperplasia and provides added benefit with nitric oxide
Kathleen G. Raman,Joel E. Barbato,Emeka Ifedigbo,Brett A. Ozanich,Mazen S. Zenati,Leo E. Otterbein,Edith Tzeng +6 more
TL;DR: CO is an effective means of reducing intimal hyperplasia in large animals after vascular injury when delivered during the operative procedure and the combination of CO and NO provided additional protection against the vascular injury response, with a greater reduction in neointima formation.
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Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury.
Martina Nowak-Machen,Moritz Schmelzle,Dusan Hanidziar,Wolfgang G. Junger,Mark A. Exley,Leo E. Otterbein,Yan Wu,Eva Csizmadia,Glen A. Doherty,Michail V. Sitkovsky,Simon C. Robson +10 more
TL;DR: It is shown that pulmonary invariant natural killer T (iNKT) cells are unexpectedly crucial in the development of acute oxygen-induced lung injury, and that tissue protection can be mediated through ATP-induced P2X7 receptor signaling, resulting in iNKT cell death.
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Alpha-2 adrenoceptor blockade protects rats against lipopolysaccharide
TL;DR: It is concluded that alpha-2 adrenergic blockade protects against LPS, either by decreasing tumor necrosis factor-alpha production or through direct effects on the target tissues of endotoxemia.
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Biliverdin protects against liver ischemia reperfusion injury in swine
Barbara Andria,A. Bracco,Chiara Attanasio,S. Castaldo,Maria Grazia Cerrito,Santolo Cozzolino,Daniele Di Napoli,Roberto Giovannoni,Antonio Mancini,Antonino Musumeci,E. Mezza,Mario Nasti,Vincenzo Scuderi,Stefania Staibano,Marialuisa Lavitrano,Leo E. Otterbein,Fulvio Calise +16 more
TL;DR: Findings in a large animal model provide strong support for the continued evaluation of biliverdin as a potential therapeutic in the clinical setting of transplantation of the liver and perhaps other organs.
Journal ArticleDOI
Carbon monoxide enhances early liver regeneration in mice after hepatectomy
Kaori Kuramitsu,David Gallo,Myunghee Yoon,Beek Yoke Chin,Eva Csizmadia,Douglas W. Hanto,Leo E. Otterbein +6 more
TL;DR: It is demonstrated that administration of exogenous CO enhances rapid and early HC proliferation and, importantly, preserves function following PHTx, and may offer a viable therapeutic option to facilitate rapid recovery following P HTx.