M
Montserrat Cols
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 30
Citations - 3033
Montserrat Cols is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: B cell & Germinal center. The author has an hindex of 17, co-authored 29 publications receiving 2554 citations. Previous affiliations of Montserrat Cols include Mount Sinai Hospital & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga,Montserrat Cols,Carolina M. Barra,Bing-Yang He,Linda Cassis,Maurizio Gentile,Laura Comerma,Alejo Chorny,Meimei Shan,Weifeng Xu,Giuliana Magri,Daniel M. Knowles,Wayne Tam,April Chiu,James B. Bussel,Sergi Serrano,José Antonio Lorente,Beatriz Bellosillo,Josep Lloreta,Nuria Juanpere,Francesc Alameda,Teresa Baró,Cristina Díaz de Heredia,Nuria Toran,Albert Català,Montserrat Torrebadell,Claudia Fortuny,Victoria Cusí,Carmen Carreras,George A. Diaz,J. Magarian Blander,Claire-Michèle Farber,Guido Silvestri,Charlotte Cunningham-Rundles,Michaela Calvillo,Carlo Dufour,Lucia Dora Notarangelo,Vassilios Lougaris,Alessandro Plebani,Jean-Laurent Casanova,Stephanie C. Ganal,Andreas Diefenbach,Juan I. Aróstegui,Manel Juan,Jordi Yagüe,Nizar Mahlaoui,Jean Donadieu,Kang Chen,Andrea Cerutti +48 more
TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.
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Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
TL;DR: This Review discusses how marginal zone B cells function as innate-like lymphocytes that mount rapid antibody responses to both T cell-dependent and Tcell-independent antigens.
Journal ArticleDOI
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Meimei Shan,Maurizio Gentile,John R. Yeiser,A. Cooper Walland,Victor Ugarte Bornstein,Kang Chen,Kang Chen,Bing He,Linda Cassis,Anna Bigas,Montserrat Cols,Laura Comerma,Bihui Huang,J. Magarian Blander,Huabao Xiong,Lloyd Mayer,Cecilia Berin,Leonard H. Augenlicht,Anna Velcich,Andrea Cerutti +19 more
TL;DR: It is shown that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs) and constrains the immunogenicity of gut antigens by delivering tolerogenic signals.
Journal ArticleDOI
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
Bing He,Raul Santamaria,Weifeng Xu,Montserrat Cols,Kang Chen,Irene Puga,Meimei Shan,Huabao Xiong,James B. Bussel,April Chiu,Anne Puel,Jeanine Reichenbach,László Maródi,Rainer Doffinger,Júlia Vasconcelos,Andrew C. Issekutz,Jens C. Krause,Graham Davies,Xiaoxia Li,Bodo Grimbacher,Alessandro Plebani,Eric Meffre,Capucine Picard,Charlotte Cunningham-Rundles,Jean-Laurent Casanova,Jean-Laurent Casanova,Andrea Cerutti,Andrea Cerutti +27 more
TL;DR: The cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor that activates transcription factor NF-κB signaling pathways via a Toll–interleukin 1 (IL-1) receptor (TIR) domain, which indicates that MyD 88 controls a B cell–intrinsic, TIR-independent, TACi-dependent pathway for immunoglobulin diversification.
Journal ArticleDOI
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells
Giuliana Magri,Michio Miyajima,Sabrina Bascones,Arthur Mortha,Irene Puga,Linda Cassis,Carolina M. Barra,Laura Comerma,Aleksey Chudnovskiy,Maurizio Gentile,David Lligé,Montserrat Cols,Sergi Serrano,Juan I. Aróstegui,Manel Juan,Jordi Yagüe,Miriam Merad,Sidonia Fagarasan,Andrea Cerutti,Andrea Cerutti +19 more
TL;DR: Stromal and myeloid signals are integrated to orchestrate innate-like antibody production at the interface between the immune system and circulatory system, and depletion of ILCs impaired both pre- and post-immune TI antibody responses.