M
Meimei Shan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 16
Citations - 3106
Meimei Shan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Immunoglobulin class switching & Antibody. The author has an hindex of 10, co-authored 13 publications receiving 2743 citations. Previous affiliations of Meimei Shan include Cornell University & National Institutes of Health.
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Journal ArticleDOI
Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL
Bing He,Weifeng Xu,Paul A. Santini,Alexandros D. Polydorides,April Chiu,Jeannelyn Santiano Estrella,Meimei Shan,Amy Chadburn,Vincenzo Villanacci,Alessandro Plebani,Daniel M. Knowles,Maria Rescigno,Andrea Cerutti +12 more
TL;DR: The authors' data indicate that bacteria elicit IgA(2) class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL.
Journal ArticleDOI
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga,Montserrat Cols,Carolina M. Barra,Bing-Yang He,Linda Cassis,Maurizio Gentile,Laura Comerma,Alejo Chorny,Meimei Shan,Weifeng Xu,Giuliana Magri,Daniel M. Knowles,Wayne Tam,April Chiu,James B. Bussel,Sergi Serrano,José Antonio Lorente,Beatriz Bellosillo,Josep Lloreta,Nuria Juanpere,Francesc Alameda,Teresa Baró,Cristina Díaz de Heredia,Nuria Toran,Albert Català,Montserrat Torrebadell,Claudia Fortuny,Victoria Cusí,Carmen Carreras,George A. Diaz,J. Magarian Blander,Claire-Michèle Farber,Guido Silvestri,Charlotte Cunningham-Rundles,Michaela Calvillo,Carlo Dufour,Lucia Dora Notarangelo,Vassilios Lougaris,Alessandro Plebani,Jean-Laurent Casanova,Stephanie C. Ganal,Andreas Diefenbach,Juan I. Aróstegui,Manel Juan,Jordi Yagüe,Nizar Mahlaoui,Jean Donadieu,Kang Chen,Andrea Cerutti +48 more
TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.
Journal ArticleDOI
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Meimei Shan,Maurizio Gentile,John R. Yeiser,A. Cooper Walland,Victor Ugarte Bornstein,Kang Chen,Kang Chen,Bing He,Linda Cassis,Anna Bigas,Montserrat Cols,Laura Comerma,Bihui Huang,J. Magarian Blander,Huabao Xiong,Lloyd Mayer,Cecilia Berin,Leonard H. Augenlicht,Anna Velcich,Andrea Cerutti +19 more
TL;DR: It is shown that the small intestine has a porous mucus layer, which permitted the uptake of MUC2 by antigen-sampling dendritic cells (DCs) and constrains the immunogenicity of gut antigens by delivering tolerogenic signals.
Journal ArticleDOI
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI.
Weifeng Xu,Bing He,April Chiu,Amy Chadburn,Meimei Shan,Malwina Buldys,Aihao Ding,Daniel M. Knowles,Paul A. Santini,Andrea Cerutti +9 more
TL;DR: ECs may function as mucosal 'guardians' orchestrating frontline IgG and IgA class switching through a Toll-like receptor–inducible signaling program regulated by secretory leukocyte protease inhibitor.
Journal ArticleDOI
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
Bing He,Raul Santamaria,Weifeng Xu,Montserrat Cols,Kang Chen,Irene Puga,Meimei Shan,Huabao Xiong,James B. Bussel,April Chiu,Anne Puel,Jeanine Reichenbach,László Maródi,Rainer Doffinger,Júlia Vasconcelos,Andrew C. Issekutz,Jens C. Krause,Graham Davies,Xiaoxia Li,Bodo Grimbacher,Alessandro Plebani,Eric Meffre,Capucine Picard,Charlotte Cunningham-Rundles,Jean-Laurent Casanova,Jean-Laurent Casanova,Andrea Cerutti,Andrea Cerutti +27 more
TL;DR: The cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor that activates transcription factor NF-κB signaling pathways via a Toll–interleukin 1 (IL-1) receptor (TIR) domain, which indicates that MyD 88 controls a B cell–intrinsic, TIR-independent, TACi-dependent pathway for immunoglobulin diversification.