L
Leonard Verhagen
Researcher at Rush University Medical Center
Publications - 10
Citations - 1258
Leonard Verhagen is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Deep brain stimulation & Disease. The author has an hindex of 4, co-authored 6 publications receiving 1091 citations. Previous affiliations of Leonard Verhagen include University of Chicago.
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Journal ArticleDOI
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
William J. Marks,Raymond T. Bartus,Joao Siffert,Charles S Davis,Andres M. Lozano,Nicholas M. Boulis,Jerrold L. Vitek,Mark Stacy,Dennis A. Turner,Leonard Verhagen,Roy A.E. Bakay,Ray L. Watts,Barton L. Guthrie,Joseph Jankovic,Richard K. Simpson,Michele Tagliati,Ron L. Alterman,Matthew B. Stern,Gordon H. Baltuch,Philip A. Starr,Paul S. Larson,Jill L. Ostrem,John G. Nutt,Karl Kieburtz,Jeffrey H. Kordower,C. Warren Olanow +25 more
TL;DR: Intraputaminal AAV2-neurturin is not superior to sham surgery when assessed using the UPDRS motor score at 12 months, however, the possibility of a benefit with additional targeting of the substantia nigra and longer term follow-up should be investigated in further studies.
Journal ArticleDOI
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
William J. Marks,Jill L. Ostrem,Leonard Verhagen,Philip A. Starr,Paul S. Larson,Roy A.E. Bakay,Robin Taylor,Deborah A. Cahn-Weiner,A. Jon Stoessl,C. Warren Olanow,Raymond T. Bartus +10 more
TL;DR: The initial data support the safety, tolerability, and potential efficacy of CERE-120 as a possible treatment for PD; however, these results must be viewed as preliminary until data from blinded, controlled clinical trials are available.
Journal ArticleDOI
Association of Subthalamic Deep Brain Stimulation With Motor, Functional, and Pharmacologic Outcomes in Patients With Monogenic Parkinson Disease: A Systematic Review and Meta-analysis
Carlo Alberto Artusi,Alok Dwivedi,Alberto Romagnolo,Gian Pal,Marcelo Andrés Kauffman,Ignacio F. Mata,Dhiren Patel,Joaquin A. Vizcarra,Andrew P. Duker,Luca Marsili,Binith Cheeran,Daniel Woo,Maria Fiorella Contarino,Leonard Verhagen,Leonardo Lopiano,Alberto J. Espay,Alfonso Fasano,Alfonso Fasano,Aristide Merola +18 more
TL;DR: Genetic screening for LRRK2, GBA, and PRKN mutations in patients with Parkinson disease who are candidates for subthalamic deep brain stimulation may serve to inform outcomes.
Journal ArticleDOI
Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies
P. Justin Rossi,Aysegul Gunduz,Jack W. Judy,Linda Wilson,Andre G. Machado,James Giordano,W. Jeff Elias,Marvin A. Rossi,Christopher L. Butson,Michael D. Fox,Cameron C. McIntyre,Nader Pouratian,Nicole C. Swann,Coralie de Hemptinne,Robert E. Gross,Howard J. Chizeck,Michele Tagliati,Andres M. Lozano,Wayne K. Goodman,Jean-Philippe Langevin,Ron L. Alterman,Umer Akbar,Greg A. Gerhardt,Warren M. Grill,Mark Hallett,Todd M. Herrington,Jeffrey Herron,Craig G. van Horne,Brian H. Kopell,Anthony E. Lang,Codrin Lungu,Daniel Martinez-Ramirez,Alon Y. Mogilner,Rene Molina,Enrico Opri,Kevin J. Otto,Karim Oweiss,Yagna Pathak,Aparna Wagle Shukla,Jonathan Shute,Sameer A. Sheth,Ludy C. Shih,G. Karl Steinke,Alexander I. Tröster,Nora Vanegas,Kareem A. Zaghloul,Leopoldo Cendejas-Zaragoza,Leonard Verhagen,Kelly D. Foote,Michael S. Okun +49 more
TL;DR: The proceedings of the 3rd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, imaging, and computational work on DBS for the treatment of neurological and neuropsychiatric disease.
Journal ArticleDOI
Parkinson disease and STN-DBS: cognitive effects in GBA mutation carriers.
Gian Pal,Graziella Mangone,Emily Hill,Bichun Ouyang,Yuanqing Liu,Vanessa Lythe,Debra Ehrlich,Rachel Saunders-Pullman,Vicki Shanker,Susan B. Bressman,Roy N. Alcalay,P. Simon Garcia,Karen Marder,Jan O. Aasly,M. Maral Mouradian,S. Link,M. Rosenbaum,Sharlet Anderson,Bryan Bernard,R. Wilson,Glenn T. Stebbins,William C. Nichols,Marie-Laure Welter,Sepehr Sani,Mitra Afshari,Leonard Verhagen,Rob M.A. de Bie,Thomas Foltynie,Deborah A. Hall,Jean-Christophe Corvol,Christopher G. Goetz +30 more
TL;DR: Although non-randomized, this composite analysis suggests that the combined effects of GBA mutations and STN-DBS negatively impact cognition and advises that DBS candidates be screened for G BA mutations as part of the pre-surgical decision-making process.