J
Jacques Arnaud
Researcher at Centre national de la recherche scientifique
Publications - 35
Citations - 741
Jacques Arnaud is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: T-cell receptor & CD3. The author has an hindex of 13, co-authored 35 publications receiving 696 citations. Previous affiliations of Jacques Arnaud include Paul Sabatier University.
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Journal ArticleDOI
Epitopes of human fibrin recognized by the rheumatoid arthritis-specific autoantibodies to citrullinated proteins
Mireille Sebbag,Nathalie Moinard,Isabelle Auger,Cyril Clavel,Jacques Arnaud,Leonor Nogueira,Jean Roudier,Guy Serre +7 more
TL;DR: The immunological conflict between ACPA and fibrin could sustain synovial inflammation not only via pro‐inflammatory effector mechanisms but also via impairment of fibrinolysis.
Journal ArticleDOI
Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases.
Marie-Claire Méchin,Mireille Sebbag,Jacques Arnaud,Rachida Nachat,C. Foulquier,Véronique Adoue,Fanny Coudane,Hélène Duplan,Anne-Marie Schmitt,Stéphane Chavanas,M. Guerrin,Guy Serre,Michel Simon +12 more
TL;DR: In this paper, the main biochemical, genetic and functional aspects of peptidylarginine deiminases (PADs) together with their pathophysiological implications are discussed.
Journal Article
Assessment of the methods for the detection of Epstein-Barr virus nucleic acids and related gene products in Hodgkin's disease.
P. Brousset,Fabienne Meggetto,Shashikant Chittal,Frédéric Bibeau,Jacques Arnaud,B. Rubin,Georges Delsol +6 more
TL;DR: ISH and immunohistochemical methods are more sensitive than Southern blot for detecting EBV in Hodgkin and Reed-Sternberg cells of Hodgkin's disease and this method offers the advantage of being applied to routinely processed tissue sections.
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Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases
Marie-Claire Méchin,Fanny Coudane,Véronique Adoue,Jacques Arnaud,Hélène Duplan,Marie Charveron,Anne-Marie Schmitt,Hidenari Takahara,Guy Serre,Michel Simon +9 more
TL;DR: Deimination can be regulated at multiple levels: transcription of the PADI genes, translation of the corresponding mRNAs, and auto-deimination of PADs.
Journal ArticleDOI
The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted.
Cristina Iobagiu,Anna Magyar,Leonor Nogueira,Martin Cornillet,Mireille Sebbag,Jacques Arnaud,Ferenc Hudecz,Guy Serre +7 more
TL;DR: It is demonstrated that only 3 immunodominant epitopes are targeted by ACPA on citrullinated fibrin stressing their actual oligoclonality, however, the reactivity to the 3 epitopes distinguishes three subgroups of patients.