Leping Cheng

TL;DR: This work identifed 1445 putative TFs in the mouse genome and found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain.

TL;DR: It is found that Tlx3 was required for specification of, and expressed in, glutamatergic neurons, and excess GABA-mediated inhibition caused dysfunction of central respiratory circuits in TlX3 mutant mice.

TL;DR: It is shown that expression of achaete-scute complex homolog-like 1 (Ascl1) alone is sufficient to convert dorsal midbrain astrocytes of mice into functional iN cells in vitro and in vivo, and GFAP–AAV is an efficient vector for generatingiN cells from astroCytes in vivo.

TL;DR: These genetic studies suggest that Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize L bx1 to promote glutamatergic differentiation.

TL;DR: A transgenic mouse is generated using an improved dCas9 system that enables simultaneous and precise in vivo transcriptional activation of multiple genes and long noncoding RNAs in the nervous system and is able to use targeted activation of endogenous neurogenic genes in these transgenic mice to directly and efficiently convert astrocytes into functional neurons in vivo.