Leslie E. Rogler

TL;DR: A role for these miRNAs in the maintenance of the malignant transformation of hepatocytes is supported, and separate treatments with antisense oligonucleotides specific for either the miR-17-92 polycistron (all six members) or mi-21 caused a 50% reduction in both hepatocyte proliferation and anchorage-independent growth.

TL;DR: The data provide a model in which miR‐23b miRNAs repress bile duct gene expression in fetal hepatocytes while promoting their growth by down‐regulating Smads and consequently TGFβ signaling.

TL;DR: Staining with NCAM, CK19, and HepPar1 has revealed a distinctly bipolar structure to DRs that are embedded in cirrhotic tissue, and the locations of other intermediate hepatobiliary cells, which have combinations of markers, suggest that CK19+/NCAM+ cells are transitional cells in the biliary lineage and that rare cells that are negative for all three markers are transitions in the hepatocytic lineage.

TL;DR: A line of hepatic endoderm cells, hepatoblast cell line 3 (HBC-3), was derived from the liver diverticulum of the mouse on day 9.5 of gestation by culture on a mitomycin C treated STON+ feeder layer in a liver culture medium consisting of Dulbecco's modified Eagle's medium, nonessential amino acids, fetal calf serum, and beta-mercaptoethanol.

TL;DR: It is shown that oncogenic microRNA, miR-21, represses RHOB expression by directly targeting the 3′ untranslated region and promotes multiple components of the metastatic phenotype in vitro by regulating several important tumor suppressors, including RHOB.