M
Margherita Melegari
Researcher at Albert Einstein College of Medicine
Publications - 2
Citations - 413
Margherita Melegari is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene knockdown & Gene. The author has an hindex of 2, co-authored 2 publications receiving 406 citations. Previous affiliations of Margherita Melegari include Yeshiva University.
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Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.
Erin Connolly,Margherita Melegari,Pablo Landgraf,Tatyana Tchaikovskaya,Bud C. Tennant,Betty L. Slagle,Leslie E. Rogler,Mihaela Zavolan,Thomas Tuschl,Charles E. Rogler +9 more
TL;DR: A role for these miRNAs in the maintenance of the malignant transformation of hepatocytes is supported, and separate treatments with antisense oligonucleotides specific for either the miR-17-92 polycistron (all six members) or mi-21 caused a 50% reduction in both hepatocyte proliferation and anchorage-independent growth.
Journal ArticleDOI
Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown.
TL;DR: A simple and effective artificial multi-hairpins method is reported that stimulates production of mature 22-nucleotide small RNAs from modified miRNA hairpins, improves gene knockdown over single-hairpin constructs, and provides linked multi-gene knockdowns.