Charles E. Rogler

TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.

TL;DR: Partial repopulation of the liver of immunodeficient urokinase‐type plasminogen activator (uPA)/recombinant activation gene‐2 (RAG‐2) mice with normal human hepatocytes isolated from the adult liver is reported, providing proof that normalhuman hepatocytes can integrate into the mouse hepatic parenchyma, undergo multiple cell divisions, and remain permissive for a human hepatotropic virus in a xenogenic liver.

TL;DR: The long latent period before tumors arise and the wide spectrum of tumor types suggest that IGF-II may function primarily as a tumor progression factor in mice via autocrine and endocrine mechanisms of action.

TL;DR: A role for these miRNAs in the maintenance of the malignant transformation of hepatocytes is supported, and separate treatments with antisense oligonucleotides specific for either the miR-17-92 polycistron (all six members) or mi-21 caused a 50% reduction in both hepatocyte proliferation and anchorage-independent growth.

TL;DR: Loss of hepatocyte growth factor expression in myofibroblast‐like cells derived from fat‐storing cells may be responsible for reduced parenchymal cell regeneration in chronic liver disease.