Lev N. Novikov

TL;DR: Alginate hydrogel transformed OECs, SCs, and BMSCs into atypical cells with spherical shape and inhibited their metabolic activity, suggesting that addition of extracellular matrix should be considered when engineering biosynthetic scaffolds on the basis of alginate Hydrogels.

TL;DR: A therapeutic potential for brain-derived neurotrophic factor is found in the early treatment of traumatic injuries to spinal nerves and roots in adult rat spinal motoneurons.

TL;DR: Human adipose-derived stem cells produce functional neurotrophic and angiogenic factors, creating a more desirable microenvironment for nerve regeneration, and their effects in a peripheral nerve injury model were determined.

TL;DR: Following ventral root avulsion and 4 weeks of continuous treatment, BDNF, but not CNTF, was found to prevent cell death and NOS expression in the lesioned motoneurons, suggesting a therapeutic potential for BDNF in the adult nervous system, possibly through blockage of nitric oxide synthesis.

TL;DR: It is demonstrated that a biodegradable tubular conduit made from poly-beta-hydroxybutyrate (PHB) scaffold promotes attachment, proliferation and survival of adult Schwann cells and supports marked axonal regeneration within the graft.