L
Lewis J. Rubin
Researcher at University of California, San Diego
Publications - 373
Citations - 60316
Lewis J. Rubin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Pulmonary hypertension & Bosentan. The author has an hindex of 101, co-authored 370 publications receiving 57044 citations. Previous affiliations of Lewis J. Rubin include University of Texas Health Science Center at San Antonio & Silver Spring Networks.
Papers
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Journal ArticleDOI
Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction
Sharon S. McDaniel,Oleksandr Platoshyn,Jian Wang,Ying Yu,Michele Sweeney,Stefanie Krick,Lewis J. Rubin,Jason X.-J. Yuan +7 more
TL;DR: The results suggest that CCE, potentially through transient receptor potential-encoded Ca(2+) channels, plays an important role in agonist-mediated PA contraction.
Journal ArticleDOI
NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels
TL;DR: It is concluded that NO promotes the opening of Kv channels in pulmonary arterial smooth muscle cells and the resulting membrane hyperpolarization, which lowers [Ca2+]i, is apparently one of the mechanisms by which NO induces pulmonary vasodilation.
Journal ArticleDOI
Endothelin receptor antagonists in pulmonary arterial hypertension.
TL;DR: Bosentan, a dual-receptor antagonist, is approved by the U.S. Food and Drug Administration for class III and IV patients with PAH, and may have a role as part of a combination of drugs such as a prostanoid or sildenafil.
Journal ArticleDOI
Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension
Carmelle V. Remillard,Donna D. Tigno,Oleksandr Platoshyn,Elyssa D. Burg,Elena E. Brevnova,Diane Conger,Ann Nicholson,Brinda K. Rana,Richard N. Channick,Lewis J. Rubin,Daniel T. O'Connor,Jason X.-J. Yuan +11 more
TL;DR: It is reported that overexpression of the Kv1.5 channel gene (KCNA5) in human PASMC and other cell lines produced a 15-pS single channel current and a large whole cell current that was sensitive to 4-aminopyridine, and novel SNPs in the promoter and translated regions of KCNA5 are present in IPAH patients.
Journal ArticleDOI
Borderline pulmonary arterial pressure is associated with decreased exercise capacity in scleroderma.
Gabor Kovacs,Robert Maier,Elisabeth Aberer,Marianne Brodmann,Stefan Scheidl,Natascha Tröster,Christian Hesse,Wolfgang Salmhofer,Winfried Graninger,Ekkehard Gruenig,Lewis J. Rubin,Horst Olschewski +11 more
TL;DR: MPAP and resistance in the upper normal range at rest and moderate exercise are associated with decreased exercise capacity and may indicate early pulmonary vasculopathy in patients with systemic sclerosis.