Li Wang

TL;DR: HPCA1, a member of a previously uncharacterized subfamily of leucine-rich-repeat receptor-like kinases, is the hydrogen-peroxide sensor at the plasma membrane in Arabidopsis and helps to identify how the perception of extracellular H2O2 is integrated with responses to various external stresses and internal cues in plants, and have implications for the design of crops with enhanced fitness.

TL;DR: These compounds potently induced degradation of mutant but not wildtype EGFR in an E3 ligase-dependent manner in cancer cell lines and effectively suppressing growth of lung cancer cells compared with the corresponding negative controls.

TL;DR: The kinetic heterogeneity results from competition between excited-state relaxation and injection as the photoexcited dye relaxes through the (3)MLCT manifold to the thermally equilibrated state, underscoring the potential for a simple kinetic model to reproduce the complex kinetic behavior often observed at the interface of mesoporous metal oxide materials.

TL;DR: Proteogenomic mapping is an approach that uses mass spectrometry data from proteins to directly map protein-coding genes and could aid in locating translational regions in the human genome.

TL;DR: In this paper, the KEAP1 E3 ligase was harnessed for targeted protein degradation utilizing a highly selective, noncovalent small-molecule KEAP 1 binder.