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Xufen Yu
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 48
Citations - 1054
Xufen Yu is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 14, co-authored 31 publications receiving 528 citations. Previous affiliations of Xufen Yu include University of Hawaii at Hilo & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
Xufen Yu,Dianqing Sun +1 more
TL;DR: The primary goal of this review is to summarize currently used macrocyclic drugs, highlight the therapeutic potential of this underexplored drug class and outline the general synthetic methodologies for the synthesis of macrocycles.
Journal ArticleDOI
Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.
Meng Cheng,Xufen Yu,Kaylene Lu,Ling Xie,Li Wang,Fanye Meng,Xiaoran Han,Xian Chen,Jing Liu,Yue Xiong,Jian Jin +10 more
TL;DR: These compounds potently induced degradation of mutant but not wildtype EGFR in an E3 ligase-dependent manner in cancer cell lines and effectively suppressing growth of lung cancer cells compared with the corresponding negative controls.
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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism
Alex J. Bott,Alex J. Bott,Jianliang Shen,Claudia Tonelli,Le Zhan,Nithya Sivaram,Nithya Sivaram,Ya Ping Jiang,Ya Ping Jiang,Xufen Yu,Vrushank Bhatt,Eric Chiles,Hua Zhong,Sara Maimouni,Weiwei Dai,Stephani Velasquez,Ji-An Pan,Nathiya Muthalagu,Jennifer P. Morton,Tracy G. Anthony,Hui Feng,Wouter H. Lamers,Daniel J. Murphy,Jessie Yanxiang Guo,Jian Jin,Howard C. Crawford,Lanjing Zhang,Eileen White,Richard Z. Lin,Richard Z. Lin,Xiaoyang Su,David A. Tuveson,Wei-Xing Zong +32 more
TL;DR: It is shown that aKG-mediated rescue of glutamine-deprived pancreatic ductal carcinoma (PDAC) cells requires glutamate ammonia ligase (GLUL), the enzyme responsible for de novo glutamine synthesis, which plays a critical role in PDAC.
Journal ArticleDOI
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Jun Wang,Xufen Yu,Weida Gong,Xijuan Liu,Kwang-Su Park,Anqi Ma,Yi-Hsuan Tsai,Yu-Ming Shen,Takashi Onikubo,Wenhu Pi,David F. Allison,Jing Liu,Wei-Yi Chen,Lin Cai,Robert G. Roeder,Jian Jin,Gang Wang +16 more
TL;DR: Zhang et al. as mentioned in this paper reported that EZH2 has additional non-canonical functions by binding cMyc at non-PRC2 targets and uses a hidden transactivation domain (TAD) for (co)activator recruitment and gene activation.
Journal ArticleDOI
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Jun Wang,Xufen Yu,Weida Gong,Xijuan Liu,Kwang-Su Park,Anqi Ma,Yi-Hsuan Tsai,Yu-Ming Shen,Takashi Onikubo,Wen Chieh Pi,David F. Allison,Jing Liu,Wei-Yi Chen,Lin Cai,Robert G. Roeder,Jian Jin,Gang Wang +16 more
TL;DR: Zhang et al. as mentioned in this paper reported that EZH2 has additional non-canonical functions by binding cMyc at non-PRC2 targets and uses a hidden transactivation domain (TAD) for (co)activator recruitment and gene activation.