L
Liam M. O'Brien
Researcher at Colby College
Publications - 31
Citations - 2391
Liam M. O'Brien is an academic researcher from Colby College. The author has contributed to research in topics: Buprenorphine & Pregnancy. The author has an hindex of 17, co-authored 31 publications receiving 2114 citations. Previous affiliations of Liam M. O'Brien include Harvard University & University of New England (United States).
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Journal ArticleDOI
Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys
Martha R. Herbert,David A. Ziegler,Curtis K. Deutsch,Liam M. O'Brien,Nicholas Lange,Anna Bakardjiev,James Hodgson,Kristen T. Adrien,Shelly Steele,Nikos Makris,David N. Kennedy,Gordon J. Harris,Verne S. Caviness +12 more
TL;DR: Results suggest that there may be differential effects driving white matter to be larger and cerebral cortex and hippocampus-amygdala to be relatively smaller in the autistic than in the typically developing brain, and suggests that there is an overall increase in brain volumes compared with controls.
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Hypothalamic Abnormalities in Schizophrenia: Sex Effects and Genetic Vulnerability
Jill M. Goldstein,Larry J. Seidman,Larry J. Seidman,Larry J. Seidman,Nikos Makris,Todd H. Ahern,Todd H. Ahern,Todd H. Ahern,Liam M. O'Brien,Verne S. Caviness,David N. Kennedy,Stephen V. Faraone,Ming T. Tsuang +12 more
TL;DR: Significant increased hypothalamic volume in cases and nonpsychotic relatives, particularly in regions of paraventricular and mammillary body nuclei, respectively is demonstrated, which was linear from simplex to multiplex cases, was positively correlated with anxiety, and had a greater propensity in women.
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Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis.
Martha R. Herbert,David A. Ziegler,David A. Ziegler,Curtis K. Deutsch,Liam M. O'Brien,David N. Kennedy,Pauline A. Filipek,A. I. Bakardjiev,J. Hodgson,Masanori Takeoka,Nikos Makris,Verne S. Caviness +11 more
TL;DR: A sizeable right-asymmetry increase reported here may be a consequence of early abnormal brain growth trajectories in children with high-functioning autism and with developmental language disorder, while higher-order association areas may be most vulnerable to connectivity abnormalities associated with white matter increases.
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Impact of Normal Sexual Dimorphisms on Sex Differences in Structural Brain Abnormalities in Schizophrenia Assessed by Magnetic Resonance Imaging
Jill M. Goldstein,Larry J. Seidman,Liam M. O'Brien,Nicholas J. Horton,David N. Kennedy,Nikos Makris,Verne S. Caviness,Stephen V. Faraone,Ming T. Tsuang +8 more
TL;DR: Sex-specific effects were primarily evident in the cortex, particularly in the frontomedial cortex, basal forebrain, cingulate and paracingulate gyri, posterior supramarginal gyrus, and planum temporale.
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Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease.
TL;DR: It is demonstrated that HDAC inhibitors like SB can ameliorate locomotor impairment in a rotenone-induced PD model and the possibility of SB-mediated protective role through mechanisms independent from dopamine system is discussed.