Liang Liu

TL;DR: Using 16 key molecular features, five prognostic subtypes were identified and a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories was developed, raising potential implications for immunotherapy.

TL;DR: The RPI-Pred (RNA-protein interaction predictor), a new support-vector machine-based method, to predict protein-RNA interaction pairs, based on both the sequences and structures, which was superior to other existing ones by predicting more experimentally validated ncRNA- protein interaction pairs from different organisms.

TL;DR: This study presents a computational approach to systematically investigating how epigenetic changes in chromatin architectures or DNA sequences relate to TF binding, and elucidates highly coordinated, but location- and cell type-specific relationships between epigenetic modifications and binding affinities of TFs.

TL;DR: Overall, this study identified the prevalent monocyte‐to‐M2 differentiation in NSCLC, accompanied by an intricate transcriptional reprogramming mediated by specific transcriptional activators and intercellular crosstalk involving ligand‐receptor interactions.

TL;DR: Analysis of HNSCC data from The Cancer Genome Atlas found increased methylation in radiation-resistant tumors, consistent with the cell culture data, and suggest a need for targeted manipulation of DNA methylation to increase radiation response in HNS CC.