Andre Schultz

TL;DR: Using 16 key molecular features, five prognostic subtypes were identified and a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories was developed, raising potential implications for immunotherapy.

TL;DR: Tumors with TP53 mutations differ from their non-mutated counterparts in RNA, miRNA, and protein expression patterns, with mutant TP53 tumors displaying enhanced expression of cell cycle progression genes and proteins.

TL;DR: This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas from five sites associated with smoking and/or human papillomavirus.

TL;DR: An integromic analysis of gene alterations that modulate transforming growth factor β-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas provides a broad molecular perspective relevant for future functional and therapeutic studies of the diverse cancer pathways mediated by the TGF-β superfamily.

TL;DR: A novel algorithm called Cost Optimization Reaction Dependency Assessment (CORDA) is introduced to build genome scale models in a tissue-specific manner and identifies changes in reactions and pathways that are differentially included and present different capacity profiles in cancer compared to healthy tissues.