L
Lifang Yu
Publications - 6
Citations - 116
Lifang Yu is an academic researcher. The author has contributed to research in topics: Gene & Apoptosis. The author has an hindex of 3, co-authored 3 publications receiving 102 citations.
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Journal ArticleDOI
Genetic deletion of AT2 receptor antagonizes angiotensin II-induced apoptosis in fibroblasts of the mouse embryo.
Wenge Li,Yizhou Ye,Bo Fu,Jianzhong Wang,Lifang Yu,Toshihiro Ichiki,Tadashi Inagami,Iekuni Ichikawa,Xiangmei Chen +8 more
TL;DR: This is the first report using a gene targeting study to demonstrate that Ang II induces apoptosis through the AT2 receptor in the fibroblasts of the mouse embryo.
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Knockdown of fibronectin induces mitochondria-dependent apoptosis in rat mesangial cells.
Di Wu,Xiangmei Chen,Deng-Fu Guo,Quan Hong,Bo Fu,Rui Ding,Lifang Yu,Kai Hou,Zhe Feng,Xiaojie Zhang,Jianzhong Wang +10 more
TL;DR: Two studies explored a new method for simultaneously inhibiting MC proliferation and ECM accumulation, which may represent a novel therapeutic approach to glomerulosclerosis.
Journal ArticleDOI
RGD-Containing Peptides Trigger Apoptosis in Glomerular Mesangial Cells of Adult Human Kidneys
TL;DR: Results indicated that both fibronECTin and vitronectin may be important in the survival of human glomerular mesangial cells and that stable cyclic RGD(D)FV peptide may be a candidate to be used for regulating apoptosis in vivo.
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Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).
Liping Liu,Rui Zhu,Jia-cheng Li,Yuan Pei,Shuangshuang Wang,Pan Xu,Mingyu Wang,Yu Wen,Hao Zhang,Daohai Du,Hong Ding,Hualiang Jiang,Kaixian Chen,Bing-Bing Zhou,Lifang Yu,Cheng Luo +15 more
TL;DR: A novel hit compound, ZL-Pin01, that covalently modified Pin1 at Cys113 with an half-maximal inhibitory concentration (IC50) of 1.33 ± 0.07 μM is identified, which could be an effective probe for studying the functional roles of Pin1.
Journal ArticleDOI
Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins.
TL;DR: In this article , the authors describe a protocol that follows the idea of the "Design-Build-Test-Learn" biological engineering cycle and makes use of dCas9/dCas12a together with their corresponding anti-CRISPR proteins (Acrs) to establish small transcriptional networks, some of which behave like Boolean gates, in Saccharomyces cerevisiae.