Lijian Chen

TL;DR: In this paper, the reticulon protein 1-C (RTN1-C) was associated with the progression of cerebral ischemia/reperfusion (I/R) injury.

TL;DR: It is determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models and may be a negative regulator of inflammation and mediate the crosstalk between the NF-κB pathway and ER stress.

TL;DR: These results demonstrate for the first time that the virulence factor ROP18 in T. gondii type I strains is responsible for inhibiting the host NF-κB pathway and for suppressing proinflammatory cytokine expression, thus providing a survival advantage to the infectious agent.

TL;DR: The role of mitochondria in liver IRI is discussed in this article, from aspects of mitochondrial oxidative stress, mitochondrial fusion and fission, mPTP formation, and corresponding protective measures.

TL;DR: These results link Toxoplasma’s effector ROP18 to RTN1-C, the CNS predominantly expressed protein, as well as ER stress-induced apoptosis via GRP78 acetylation, which may provide new insight into the preferential invasion of the central nervous system by Toxplasma.