D
De-Hua Lai
Researcher at Sun Yat-sen University
Publications - 72
Citations - 2438
De-Hua Lai is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Trypanosoma brucei & Toxoplasma gondii. The author has an hindex of 20, co-authored 59 publications receiving 2018 citations. Previous affiliations of De-Hua Lai include University of Oxford & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Clonorchiasis: a key foodborne zoonosis in China
TL;DR: A background on the parasite and its life cycle is provided, key aspects regarding the pathogenesis, diagnosis, and treatment of clonorchiasis are summarized, the geographic distribution and prevalence are described, and some recommendations for future research and the control of this important disease are made.
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Trypanosoma evansi and Surra: A Review and Perspectives on Origin, History, Distribution, Taxonomy, Morphology, Hosts, and Pathogenic Effects
Marc Desquesnes,Philippe Holzmuller,De-Hua Lai,A.P. Dargantes,Zhao-Rong Lun,Sathaporn Jittaplapong +5 more
TL;DR: Surra is a major disease in camels, equines, and dogs, in which it can often be fatal in the absence of treatment, and exhibits nonspecific clinical signs, which are variable from one host and one place to another; however, its immunosuppressive effects interfering with intercurrent diseases or vaccination campaigns might be its most significant and questionable aspect.
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Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei.
De-Hua Lai,Hassan Hashimi,Hassan Hashimi,Zhao-Rong Lun,Francisco J. Ayala,Julius Lukeš,Julius Lukeš +6 more
TL;DR: It is shown that both species are actually strains of T. brucei equiperdum and T. evansi, which lost part (Dk) or all (Ak) of their kDNA, and these trypanosomes are not monophyletic clades and do not qualify for species status.
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Trypanosoma evansi and Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects
Marc Desquesnes,A.P. Dargantes,De-Hua Lai,Zhao-Rong Lun,Philippe Holzmuller,Sathaporn Jittapalapong +5 more
TL;DR: A brief review of the basic knowledge of T. evansi suggests that there is renewed interest in the parasite, which is spreading and has a major economic impact.
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Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty
Jason Carnes,Atashi Anupama,Oliver Balmer,Andrew P. Jackson,Michael D. Lewis,Rob Brown,Igor Cestari,Marc Desquesnes,Claire Gendrin,Christiane Hertz-Fowler,Hideo Imamura,Alasdair Ivens,Luděk Kořený,De-Hua Lai,Annette MacLeod,Suzanne M. McDermott,Christopher Merritt,Severine Monnerat,Wonjong Moon,Peter J. Myler,Isabelle Phan,Gowthaman Ramasamy,Dhileep Sivam,Zhao-Rong Lun,Julius Lukeš,Kenneth Stuart,Achim Schnaufer +26 more
TL;DR: The elucidation of the T. evansi genome sequence reveals extensive similarity with T. brucei and supports the contention that T.evansi should be classified as a subspecies of T. Brucei.